孕妇促甲状腺激素检测在预防碘缺乏病中的价值

The value of thyroid stimulating hormone detection of pregnant women in the prevention of iodine deficiency disorders

目的 探讨孕妇促甲状腺激素(TSH)的分泌水平和孕妇游离活性三碘甲腺原氨酸(FT3)、游离四碘甲状腺原氨酸(FT4)、尿碘水平的关系。方法 本次研究时间为2019年5月—2021年2月,研究对象为211例孕妇。研究组:选取124例住院碘缺乏孕妇,平均年龄(24.6±2.2)岁,平均胎龄(32.4±1.6)周。对照组:选取非碘缺乏孕妇87例,平均年龄(26.7±1.9)岁,平均胎龄(31.6±2.3)周。放射免疫分析(IRMA)法进行相关数据检测,分析两组孕妇的检测结果。结果 对照组FT、FT和尿碘水平均明显高于研究组,TSH水平低于研究组,差异均有统计学意义(P<0.05),且与孕妇的血清TSH值呈负相关。结论 对于碘缺乏的孕妇进行TSH水平检测能够显示孕妇的甲状腺功能和碘营养水平,作为临床检测方法,值得在孕妇预防碘缺乏病工作中推广应用。

Objective To investigate the relationship between the secretion level of thyroid stimulating hormone(TSH)and the levels of free triiodothyronine(FT3),free triiodothyronine(FT4)and urinary iodine in pregnant women.Methods The study was conducted from May 2019 to February 2021,the study subjects were 211 pregnant women.Study Group:124 hospitalized pregnant women with iodine deficiency were selected,with an average age of(24.6±2.2)years old and an average gestational age of(32.4±1.6)weeks.Control group:87 pregnant women without iodine deficiency were selected,with an average age of(26.7±1.9)years old and an average gestational age of(31.6±2.3)weeks.The relevant data were detected by radioimmunoassay(IRMA),and the test results of the two groups of pregnant women were analyzed.Results The levels of FT,FTand urinary iodine in the control group were significantly higher than those in the study group,the level of TSH was lower than that in the study group,and the differences were statistically significant(P<0.05).There was a negative correlation with the serum TSH value of pregnant women.Conclusion TSH level detection for iodine deficient pregnant women could show the thyroid function and iodine nutrition level of pregnant women.As a clinical detection method,it was worth popularizing and applying in the prevention of iodine deficiency disorders in pregnant women.