奥氮平联合利培酮对老年精神分裂症患者的疗效

Olanzapine combined with risperidone in elderly patients with schizophrenia

目的:评估与分析奥氮平联合利培酮对老年精神分裂症患者的疗效。方法:选取168例在国药中铁精神病医院进行治疗的老年精神分裂症患者作为研究对象,通过随机分组法将其分成单一用药组与联合用药组,其中前者通过奥氮平片进行治疗,后者通过奥氮平片与利培酮片联合用药进行治疗。对2组患者治疗前后临床症状和认知功能情况进行分析评估,并对临床疗效以及用药后不良反应发生率进行统计。通过ELISA法对患者治疗前后血清白细胞介素-6(interleukin-6,IL-6)、IL-17以及肿瘤坏死因子α(tumor necrosis factor α,TNF-α)水平进行检测。结果:治疗后,联合用药组的阳性症状以及阴性症状量表(Positive and Negative Syndrome Scale,PANSS)评分显著低于单一用药组(P=0.0129)。与单一用药组患者相比,联合用药组患者的总有效率明显提高(P=0.0399);在不良反应发生率方面,2组间差异无统计学意义(均P>0.05)。2组患者治疗后血清中IL-6、IL-17和TNF-α水平较治疗前明显下降,而且联合用药组降低幅度大于单一用药组(均P<0.05)。结论:奥氮平联合利培酮治疗可有效改善老年精神分裂症患者的临床症状及认知功能,在提高对老年患者治疗疗效的同时未增大药物的不良反应,并可减轻患者的炎症反应,整体治疗效果佳。

Objective:To evaluate and analyze the efficacy of olanzapine combined with risperidone in elderly patients with schizophrenia.Methods:A total of 168 elderly patients with schizophrenia treated in our hospital were selected.They were randomly divided into a single drug group and a combined drug group.The former was treated with olanzapine tablets,and the latter was treated with olanzapine tablets and risperidone tablets.The clinical symptoms and cognitive function of the 2 groups were analyzed and evaluated before and after treatment,and the clinical efficacy and the incidence of adverse reactions after treatment were counted.The levels of serum interleukin-6(IL-6),IL-17 and tumor necrosis factor α(TNF-α) were detected by enzyme-linked immunosorbent assay.Results:After treatment,the Positive and Negative Syndrome Scale(PANSS) score of the combined drug group was significantly lower than that of the single drug group(P=0.0129).Compared with patients in the single drug group,the total effective rate of patients in the combined drug group was significantly improved(P=0.0399).There was no significant difference in the incidence of adverse reactions between the 2 groups(P>0.05).The levels of serum IL-6,IL-17 and TNF-α in the 2 groups before and after treatment were detected,and it was found that they decreased significantly after treatment,and the reduction range in the combined drug group was greater than that in the single drug group(all P<0.05).Conclusion:Olanzapine combined with risperidone in the treatment of elderly patients with schizophrenia can effectively improve their clinical symptoms and cognitive function,while improve the therapeutic effect without increasing drug side effects,and can reduce the inflammatory reaction of patients.The overall therapeutic effect is good.