温阳利水汤加减联合酒石酸美托洛尔应用于慢性心力衰竭患者的临床效果分析

Effect observation of modified Wenyang Lishui decoction combined with metoprolol tartrate in patients with chronic heart failure

目的探究温阳利水汤加减联合酒石酸美托洛尔对慢性心力衰竭的治疗效果,为临床治疗提供参考。方法选取2019年1月至2020年12月广州市中西医结合医院收治的100例慢性心力衰竭患者为研究对象进行回顾性分析,根据治疗方式的不同分为研究组(50例,采用温阳利水汤加减方联合酒石酸美托洛尔治疗)和对照组(50例,采用酒石酸美托洛尔治疗)。比较两组患者的临床疗效、治疗前后心功能指标、C反应蛋白(CRP)、运动耐力、不良反应发生情况。结果研究组患者的总有效率高于对照组(P<0.05);治疗后两组患者的左室舒张末期内径、左室收缩末期内径小于治疗前,左室射血分数大于治疗前(P<0.05);治疗后研究组患者的左室舒张末期内径、左室收缩末期内径小于对照组,左室射血分数大于对照组(P<0.05);治疗后两组患者6 min步行距离长于治疗前,CRP水平低于治疗前(P<0.05),治疗后研究组患者6 min步行距离长于对照组,CRP水平低于对照组(P<0.05)。两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论温阳利水汤加减联合酒石酸美托洛尔对慢性心力衰竭有显著疗效和良好的安全性,可改善患者心功能、运动耐力、炎症反应程度。

Objective To explore the therapeutic effect of modified Wenyang Lishui Decoction combined with metoprolol tartrate on chronic heart failure and evaluate the effect on patients,so as to provide for clinical treatment reference.Methods A retrospective study was conducted on 100 patients who were treated in Guangzhou Hospital of Integrated Traditional and West Medicine due to chronic heart failure from January 2019 to December 2020.50 patients who received Wenyang Lishui Decoction plus or minus prescription were set as the study group,and 50 patients who received metoprolol tartrate were set as the control group.The clinical efficacy,adverse reactions,cardiac function indexes,C-reactive protein(CRP)and exercise tolerance before and after treatment were compared between the two groups.Results The total effective rate of study group was higher than that of control group(P<0.05).After treatment,left ventricular end-diastolic diameter and left ventricular end-systolic diameter of the two groups were lower than those before treatment,and left ventricular ejection fraction was higher than that before treatment(P<0.05).After treatment,the left ventricular end-diastolic diameter and left ventricular end-systolic diameter of the study group were lower than those of the control group,and the left ventricular ejection fraction were higher than that of the control group(P<0.05).After treatment,the 6-min walking distance of the two groups were longer than that before treatment,and the CRP level were lower than that before treatment(P<0.05).After treatment,the 6-min walking distance of patients in the study group were longer than that in the control group,and the CRP level were lower than that in the control group(P<0.05).There were no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Wenyang Lishui Decoction combined with metoprolol tartrate has significant curative effect and safety on chronic heart failure,and can improve patients’cardiac function,exercise tolerance and inflammatory response.