基因多态性与男性不育关系的研究进展

Research Progress on Gene Polymorphism and Male Infertility

遗传基因多态性是除生殖系统感染因素、炎症性功能减退、年龄等非遗传因素外导致男性不育的主要原因之一。鱼精蛋白(PRM)、雄激素受体(AR)、亚甲基四氢叶酸还原酶(MTHFR)、谷胱甘肽S-转移酶(GSTs)在精子发生、成熟及受精过程及精子DNA保护具有重要作用。PRM、AR、MTHFR、GSTs基因点位异常是男性不育的危险因素,与男性不育存在较强相关性。研究参与精子发生相关的基因多态性有助于揭示男性不育病理机制,对男性不育的诊断和治疗具有重要意义。本文主要综述PRM、AR、MTHFR、GSTs基因多态性与男性不育的研究进展。

Genetic gene polymorphism is one of the main causes of male infertility in addition to reproductive system infectious factors,inflammatory dysfunction,age and other non-genetic factors.Protamine(PRM),androgen receptor(AR),methylenetetrahydrofolate reductase(MTHFR),and glutathione S-transferases(GSTs) play an important role in spermatogenesis,maturation,and fertilization and DNA protection in sperm.Abnormal gene sites of PRM,AR,MTHFR and GSTs are risk factors of male infertility,which are correlated with male infertility.Therefore,the study of gene polymorphisms involved in spermatogenesis is helpful to reveal the relationship between male infertility and spermatogenesis and is important for the diagnosis and treatment of male infertility.This review focuses on the research progress of PRM,AR,MTHFR,GSTs gene polymorphisms and male infertility.