摘要
脑内过多的β淀粉样蛋白(Aβ)清除主要通过自噬-溶酶体系统、星形胶质细胞分泌的蛋白酶、小胶质细胞吞噬作用进行降解清除,还可通过血脑屏障和/或脑淋巴引流系统转运排出,脾主运化功能在Aβ降解和转运过程中起着重要作用。大量实验证据表明,温脾化饮法的代表方苓桂术甘汤可能影响Aβ代谢途径的关键结构和功能。在阐述Aβ代谢途径相关机制及分析苓桂术甘汤药理作用的基础上,探讨苓桂术甘汤“运化并举”实现Aβ清除的科学内涵,以期开拓中医治疗阿尔茨海默病的思路。
The clearance of excessiveβ-amyloid(Aβ)in the brain is mainly degraded and cleared by autophagy lysosomal system,protease secreted by astrocytes and phagocytosis of microglia.It can also be transported and discharged through blood-brain barrier or brain lymphatic drainage system.The function of spleen in regulating transportation and transformation Aβmetabolism plays an important role.Many experimental evidence shows that Linggui Zhugan decoction,the representative of Wenpi Huayin method,may affect Aβstructures and functions of metabolic related pathways.This paper discusses the scientific connotation transportation and transformation for clear Aβbased on the mechanism of Aβmetabolic pathway and the analysis of the pharmacological effect of Linggui Zhugan decoction,in order to explore the idea of traditional Chinese medicine treatment of Alzheimer's disease.
作者
王莉兰
周春祥
WANG Li-lan;ZHOU Chun-xiang(School of Chinese Medicine,School of Integrated Chinese and Western Medicine,Nanjing University of Chinese Medicine,Nanjing 210023,China;Department of TCM,Nanjing Mingji Hospital,Nanjing 210019,China)
出处
《南京中医药大学学报》
CAS
CSCD
北大核心
2022年第9期790-796,共7页
Journal of Nanjing University of Traditional Chinese Medicine
基金
国家自然科学基金面上项目(81774021,82074504)。
关键词
脾主运化
Β淀粉样蛋白
苓桂术甘汤
阿尔茨海默病
spleen dominates transportation and transformation
β-amyloid protein
Linggui Zhugan Decoction
Alzheimer's disease