盐酸氨溴索联合多索茶碱对慢性支气管炎患者肺功能、血清炎症因子及生活质量的影响

Effects of ambroxol hydrochloride combined with doxofylline on pulmonary function,serum inflammatory factors and quality of life in patients with chronic bronchitis

目的 探讨盐酸氨溴索联合多索茶碱对慢性支气管炎患者肺功能、血清炎症因子及生活质量的影响。方法 选取2019年1月至2020年12月于我院就诊的80例慢性支气管炎患者作为研究对象,按照治疗方案的差异将其分为对照组和观察组,每组40例。对照组给予多索茶碱治疗,观察组给予盐酸氨溴索联合多索茶碱治疗。比较两组的治疗效果。结果 观察组的喘息、咳嗽咳痰、呼吸困难及肺部啰音消失时间均短于对照组,差异具有统计学意义(P<0.05)。治疗后,观察组的动脉血氧分压(PaO_(2))、动脉血二氧化碳分压(PaCO_(2))及碳酸氢根离子(HCO3-)水平均优于对照组,差异具有统计学意义(P<0.05)。治疗后,观察组的第1秒用力呼气量(FEV1)、第1秒用力呼气量占用力肺活量百分比(FEV1/FVC)、最大呼气中期流速(MMFR)、潮气量(VT)均优于对照组,差异具有统计学意义(P<0.05)。治疗后,观察组的C-反应蛋白(CRP)、白介素-6(IL-6)、白细胞介素-1受体1型(IL-1R1)、巨噬细胞炎症蛋白-1α(MIP-1α)水平均低于对照组,差异具有统计学意义(P<0.05)。治疗后,观察组的慢性呼吸系统疾病问卷(CRQ)、世界卫生组织生存质量测定量表(WHOQOL-100)评分均优于对照组,差异具有统计学意义(P<0.05)。结论 盐酸氨溴索联合多索茶碱治疗慢性支气管炎的效果显著,可明显改善喘息、咳嗽等症状、血气指标及肺功能指标,降低血清炎性因子水平,提高生活质量,值得临床参考及推广。

Objective To investigate the effects of ambroxol hydrochloride combined with doxofylline on pulmonary function,serum inflammatory factors and quality of life in patients with chronic bronchitis.Methods A total of 80 patients with chronic bronchitis who were treated in our hospital from January 2019 to December 2020 were selected as the research objects and divided into control group and observation group according to the difference of treatment plan,with 40cases in each group.The control group was treated with doxofylline,and the observation group was treated with ambroxol hydrochloride combined with doxofylline.The treatment effects of the two groups were compared.Results The disappearance time of wheezing,cough and sputum,dyspnea and lung rales in the observation group were shorter than those in the control group,and the differences were statistically significant(P<0.05).After treatment,the levels of arterial partial pressure of oxygen(PaO_(2)),arterial partial pressure of carbon dioxide(PaCO_(2)) and HCO3-in the observation group were better than those in the control group,and the differences were statistically significant(P<0.05).After treatment,the forced expiratory volume in the first second(FEV1),the forced expiratory volume in the first second/forced vital capacity(FEV1/FVC),maximum mid-expiratory flow rate(MMFR) and tidal volume(VT) in the observation group were better than those in the control group,and the differences were statistically significant(P <0.05).After treatment,the levels of C-reactive protein(CRP),interleukin-6(IL-6),interleukin-1 receptor 1(IL-1R1) and macrophage inflammatory protein-1α(MIP-1α) in the observation group were lower than those in the control group,and the differences were statistically significant(P <0.05).After treatment,the scores of Chronic Respiratory Disease Questionnaire(CRQ) and World Health Organization Quality of Life-100(WHOQOL-100) in the observation group were better than those in the control group,and the differences were statistically significant(P<0.05).Conclusion Ambroxol hydrochloride combined with doxofylline in the treatment of chronic bronchitis has a significant effect,which can significantly ameliorate wheezing,cough and other symptoms,blood gas indexes and pulmonary function indexes,reduce the level of serum inflammatory factors,and improve the quality of life.It is worthy of clinical reference and promotion.