经皮冠状动脉介入术围术期大剂量阿托伐他汀强化治疗对冠心病患者心功能及预后的影响

Effect of perioperative intensive treatment with high-dose atorvastatin on cardiac function and prognosis in patients with coronary heart disease undergoing percutaneous coronary intervention

目的 探讨经皮冠状动脉介入术(PCI)围术期大剂量阿托伐他汀强化治疗对冠心病(CHD)患者心功能及预后的影响。方法 选取2020年1月至12月于我院拟实施PCI的90例CHD患者为研究对象,依据入院编号的奇偶性将其分为对照组与观察组,每组45例。对照组给予常规阿托伐他汀治疗方案,观察组给予围术期大剂量阿托伐他汀强化治疗方案。比较两组的治疗效果。结果 术后6个月,观察组的左室射血分数(LVEF)高于对照组,左室收缩末期容积(LVESV)、左室舒张末期容积(LVEDV)、左室后壁舒张末期厚度(LVPWT)小于对照组(P<0.05)。术后6个月,观察组的总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、肿瘤坏死因子-α(TNF-α)水平均显著低于对照组,高密度脂蛋白胆固醇(HDL-C)水平显著高于对照组(P<0.05)。观察组的不良事件总发生率显著低于对照组(P<0.05)。结论 PCI围术期大剂量阿托伐他汀强化治疗在CHD患者中的应用效果显著,可显著改善患者的心功能及血脂代谢指标。

Objective To investigate the effect of perioperative intensive treatment with high-dose atorvastatin on cardiac function and prognosis in patients with coronary heart disease(CHD) undergoing percutaneous coronary intervention(PCI).Methods A total of 90 patients with CHD planned to undergo PCI in our hospital from January to December 2020 were selected as the research objects.According to the parity of admission numbers,the patients were divided into control group and observation group,with 45 cases in each group.The control group was given conventional atorvastatin treatment,while the observation group was given perioperative intensive treatment with high-dose atorvastatin.The treatment effects of the two groups were compared.Results At 6 months after operation,the left ventricular ejection fraction(LVEF) of the observation group was higher than that of the control group,and left ventricular end-systolic volume(LVESV),left ventricular end-diastolic volume(LVEDV) and left ventricularposterior wall thickness(LVPWT) were lower than those of the control group(P <0.05).At 6 months after operation,the levels of total cholesterol(TC),triglyceride(TG),low-density lipoprotein cholesterol(LDL-C) and tumor necrosis factor-α(TNF-α) in the observation group were significantly lower than those of the control group,and the level of high-density lipoprotein cholesterol(HDL-C) was significantly higher than that of the control group(P<0.05).The total incidence of adverse events in the observation group was significantly lower than that in the control group(P <0.05).Conclusion Perioperative intensive treatment of PCI with high-dose atorvastatin in patients with CHD has a significant effect,which can significantly improve the patient’s cardiac function and blood lipid metabolism indexes.