休眠单体策略在高分子序列调控中的研究进展

Recent Advances of Polymer Sequence Regulation via Latent Monomer Strategy

序列是指高分子链中的单体单元通过共价键连接的次序。自然界中的生物大分子,如蛋白质和DNA等,他们的精确序列结构决定了其复杂且精密的功能。受此启发,序列可控高分子的合成及其结构性能研究日益成为高分子学科的热点,受到越来越多研究者关注。本文聚焦于近年来在序列调控中的重要成果,重点介绍本课题组提出的休眠单体策略在序列可控高分子合成中的研究进展。最后,基于这些研究进展对休眠单体策略进行了总结和展望。

The precisely-defined sequence structures of biomacromolecules,e.g.,protein and DNA,enable the sophisticated and unique functions.Inspired by this,polymer scientists have made enormous efforts to achieve the precise sequence regulation in synthetic polymers.Up to date,a variety of approaches toward efficient sequence-regulation based on stepgrowth and chain-growth polymerization have been developed.This review summarizes the recent progress on the sequence regulation approaches,and highlights the latent monomer strategy for sequence regulation.The latent monomer strategy for sequence regulation developed by our group relies on the thermal-responsive furan/maleimide Diels-Alder reaction.By programmatically manipulation of the polymerization temperature,varieties of sequence-controlled structures are readily produced.Moreover,this approach also bridges from sequence-controlled polymers to graft copolymers with functions and architectures.Finally,a critical outlook on the latent monomer strategy and future research directions are also provided.