期刊文献+

The role of hemoglobin in nitric oxide transport in vascular system 被引量:1

原文传递
导出
摘要 Nitric oxide(NO)plays a pivotal role in vascular homeostasis and its functions practice in a dose-dependent manner in which too high and too low NO concentration may both induce the development of cardiovascular diseases,which indicates the balance between NO formation and scavenging is critical.Evidence presented over the last two decades has indicated hemoglobin(Hb)can affect NO dynamic equilibrium.The role of Hb was once thought to play in NO signaling as inhibiting NO transport,but now several mechanisms have found that Hb may preserve and even regulate NO activity.Despite the tremendous amount of work devoted to this field,major questions concerning precise mechanisms of NO activity preservation as well as if and how Hb creates NO activity remain unanswered.In this review,we discuss the role of hemoglobin in NO formation,transport and consumption.We also discuss how these mechanisms of the imbalance between NO and hemoglobin induce related diseases,which may serve as the basis for novel therapeutics.
出处 《Medicine in Novel Technology and Devices》 2020年第1期1-6,共6页 医学中新技术与新装备(英文)
基金 supported by the National Natural Science Research Foundation of China Grants-in-Aid(grant nos.11827803,31570947,11772036,31971244,11421202 and 61533016) the 111 Project(B13003).
  • 相关文献

引证文献1

二级引证文献2

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部