敏感性皮肤的成因与发生机制研究进展

Research progress of causes and pathogenesis of sensitive skin

敏感性皮肤的成因及发病机制较为复杂,结合既往研究成果,对敏感性皮肤的成因及发生机制进行归纳总结。敏感性皮肤的成因主要包括各种外在因素、内在因素和其他皮肤病相关因素;机制复杂多样,皮肤屏障功能受损与表皮微生物状态改变、皮肤感觉神经纤维功能异常、TRPV1通道激活、皮肤神经-血管-免疫炎症通路,以及转录组学等,常由多种机制共同参与形成。对于敏感性皮肤的成因和机制的讨论分析有助于指导临床诊疗实践。

The causes and pathogenesis of sensitive skin are relatively complex.Herein,the causes and pathogenesis of sensitive skin are summarized based on previous research results.The causes of sensitive skin mainly include various external factors,internal factors and other dermatological factors.The mechanisms are complex,including skin barrier function injury,changes in epidermal microbial status,abnormal sensory nerve fiber function,activation of TRPV1 channel,neurovascular-immune-inflammatory pathway,transcriptome,etc.Sensitive skin is often induced by multiple mechanisms.The analysis and discussion of the causes and mechanisms of sensitive skin will be helpful to guide clinical practice.