摘要
目的 利用IDEAL-IQ技术定量参数脂肪分量(FF)和弛豫率(R_(2)^(*))对急性胰腺炎(AP)患者胰腺内脂肪沉积和铁沉积进行量化评估,评价其诊断AP的效能。方法 纳入2020年10月—2021年10月于内蒙古科技大学包头医学院第一附属医院诊治的AP患者72例为AP组,以同期82例健康体检者为对照组。两组研究对象应用GE 3.0T MRI行腹部IDEAL-IQ序列检查,并在MR后处理工作站测量胰腺FF及R_(2)^(*)值。符合正态性分布的计量资料两组间比较采用t检验;不符合正态分布的计量资料两组间比较采用非参数Mann-Whitney U检验。差异有统计学意义的参数进行受试者工作特征曲线分析。以曲线下面积作为评价参数诊断效能的指标。结果 病例组中FF值显著高于对照组(Z=-10.01,P<0.001),AP组中R_(2)^(*)值高于对照组,差异有统计学意义(Z=-3.73,P<0.001);而轻度与中重度AP间FF和R_(2)^(*)值的差异均无统计学意义(P值均> 0.05);FF值和R_(2)^(*)值诊断AP的敏感度分别为100%、48.6%,特异度分别为90.2%、86.6%。结论 磁共振IDEAL-IQ技术定量参数FF值诊断AP的灵敏度和特异度均较高,是诊断AP的特异性指标,具有很好的临床应用前景。
Objective To perform quantitative evaluation of fat and iron deposition in the pancreas of patients with acute pancreatitis(AP) based on the IDEAL-IQ quantitative parameters fat fraction(FF) and relaxation rate(R_(2)^(*)),and to investigate the efficacy of this technique in the diagnosis of AP.Methods A total of 72 patients with AP who were diagnosed and treated in The First Affiliated Hospital of Baotou Medical College,Inner Mongolia University of Science and Technology from October 2020 to October 2021,were enrolled as case group,and 82 healthy controls who underwent physical examination during the same period of time were enrolled as control group.The abdominal IDEAL-IQ sequence test was performed for both groups using GE 3.0 T magnetic resonance instrument,and FF and Rvalues were measured on post-processing workstation.The t-test was used for comparison of normally distributed continuous data between groups,and the Mann-Whitney U test was used for comparison of non-normally distributed continuous data between groups.A receiver operating characteristic(ROC) curve analysis was performed for the parameters with statistical significance,and area under the ROC curve(AUC) was used to evaluate the diagnostic efficacy of parameters.Results Compared with the control group,the case group had significantly higher FF value(Z=-10.01,P<0.001) and R_(2)^(*) value(Z=-3.73,P<0.001),while there were no significant differences in FF and R_(2)^(*) values between mild AP and moderate-to-severe AP(P>0.05).FF value had a sensitivity of 100% and a specificity of 90.2% in the diagnosis of AP,while R_(2)^(*) value had a sensitivity of 48.6% and a specificity of 86.6% in the diagnosis of AP.Conclusion The quantitative parameter FF value of magnetic resonance IDEAL-IQ technique has relatively high sensitivity and specificity in the diagnosis of AP,and it is a specific index for the diagnosis of AP and holds promise for clinical application.
作者
范慧芳
陈强
原小军
罗琳
FAN Huifang;CHEN Qiang;YUAN Xiaojun;LUO Lin(Baotou Medical College,Inner Mongolia University of Science and Technology,Baotou,Inner Mongolia Autonomous Region 014040,China;Department of Medical Radiology,The First Affiliated Hospital of Baotou Medical College,Inner Mongolia University of Science and Technology,Baotou,Inner Mongolia Autonomous Region 014010,China)
出处
《临床肝胆病杂志》
CAS
北大核心
2022年第10期2320-2324,共5页
Journal of Clinical Hepatology
基金
包头医学院科学研究基金项目(BYJJ-QM201753)。