炎症在肝纤维化中的作用

Role of inflammation in hepatic fibrosis

慢性肝损伤引起的炎症反应是肝纤维化发生发展的主要病理因素。在肝纤维化发展的过程中,大量炎症信号被激活,促使肝星状细胞向肌成纤维细胞转化,最终导致肝脏中细胞外基质的大量分泌和沉积,形成瘢痕组织。本文综述了肝星状细胞、Kupffer细胞、炎症小体、炎症信号通路等在肝纤维化过程中的作用,以对临床诊断和治疗提供参考。

Inflammation caused by chronic liver is primarily responsible for the occurrence and pathological progression of liver fibrosis.In the process of liver fibrosis,a large number of activated inflammatory signals promote the transformation of hepatic stellate cells(HSC) into myofibroblasts(MF),which eventually leads to the massive secretion and deposition of extracellular matrix(ECM) and the formation of scar tissue in the liver.To provide literature references for clinical diagnosis and treatment,this paper reviews the roles of HSC,Kupffer cells(KC),inflammasomes and inflammatory signaling in liver fibrosis.