人类疱疹病毒7型肺炎一例

Human herpesvirus type 7 pneumonia:a case report

人类疱疹病毒7型(HHV-7)肺炎罕见。该文报道1例HHV-7肺炎病例,患者以咳嗽、咳痰、发热为临床表现,胸部CT表现为双肺片絮状密度增高影、结节伴晕征、进展空洞。常规抗感染治疗效果欠佳,后经支气管肺泡灌洗液(BALF)行宏基因组二代测序确诊,加用更昔洛韦抗病毒后病情好转。该例诊治提示,HHV-7肺炎临床症状不典型,影像学表现无特异性,对于早期抗感染治疗效果不佳的患者,应及时行BALF宏基因组二代测序检测有助于明确诊断。

Human herpesvirus 7(HHV7) pneumonia is rare.In this article,one case of HHV-7 pneumonia was reported.The clinical manifestations were cough,expectoration,and fever.CT scan of the chest showed flocculent dense shadows,nodules accompanied by halo signs,and progressive cavities.Conventional anti-infection therapy yielded low efficacy.The diagnosis was confirmed by metagenomic next-generation sequencing(mNGS) in bronchoalveolar lavage fluid(BALF),and the condition was improved after adding ganciclovir.The diagnosis and treatment of this case suggest that clinical symptoms of HHV-7 pneumonia are atypical and imgaing manifestations are non-specific.BALF-mNGS contributes to confirming the diagnosis for patients who are not effectively treated with early anti-infection therapy.