甲氨蝶呤联合正清风痛宁缓释片治疗活动期类风湿关节炎的疗效观察

Effect of methotrexate combined with Zhengqing Fengtongning sustained release tablets in the treatment of active rheumatoid arthritis:an observation study

目的观察甲氨蝶呤联合正清风痛宁缓释片治疗活动期类风湿关节炎的临床疗效。方法选择120例活动期类风湿关节炎患者作为研究对象,并将其随机分为研究组和对照组,每组60例。对照组给予非甾体类抗炎药配合甲氨蝶呤治疗,研究组在此基础上加用正清风痛宁缓释片,两组均治疗12周。比较治疗前、治疗12周后两组患者关节状况、疼痛视觉模拟量表(VAS)评分、疾病活动评分28(DAS28)评分、生活质量综合评定量表(GQOL-74)评分、实验室指标[类风湿因子(RF)、红细胞沉降率(ESR)、C反应蛋白(CRP)]和治疗12周后的临床疗效。结果治疗12周后,两组患者晨僵时间、压痛关节数、肿胀关节数、疼痛VAS评分、DAS28评分,以及RF、ESR、CRP水平均减少(下降),握力、GQOL-74评分均增加,且研究组患者上述指标改善均优于对照组(均P<0.05)。治疗12周后,研究组治疗总有效率(93.33%)高于对照组(78.33%)(P<0.05)。结论甲氨蝶呤联合正清风痛宁缓释片治疗活动期类风湿关节炎可改善患者临床症状并提升其生活质量,临床疗效显著,值得推广使用。

Objective To observe the effect of methotrexate combined with Zhengqing Fengtongning sustained release tablets in the treatment of active rheumatoid arthritis.Methods A total of 120 patients with active rheumatoid arthritis were selected as research subjects and randomly divided into a study group or a control group,with 60 patients in each group.The control group was treated with non-steroidal anti-inflammatory drugs combined with methotrexate,based on which the study group was treated with Zhengqing Fengtongning sustained release tablets additionally;both groups were treated for 12 weeks.The followings were compared between the two groups before the treatment and after the 12-week treatment,including the joint condition,pain Visual Analog Scale(VAS)score,Disease Activity Score 28(DAS28)score,Generic Quality of Life Inventory 74(GQOL-74)score,and the laboratory indicators(rheumatoid factor[RF],erythrocyte sedimentation rate[ESR],C-reactive protein[CRP]),as well as the clinical effect after the 12-week treatment.Results After the 12-week treatment,the time for morning stiffness,numbers of joints with tenderness,numbers of swelling joints,pain VAS scores,DAS28 scores,as well as the RF,ESR,and CRP levels decreased,while the gripping power and GQOL-74 scores increased in the two groups.The aforementioned indexes were superior in the study group than in the control group(all P<0.05).After the 12-week treatment,the study group had a higher total effective rate than the control group(93.33%vs.78.33%)(P<0.05).Conclusion The combined application of methotrexate and Zhengqing Fengtongning sustained release tablets can improve the clinical symptoms and life quality of patients with active rheumatoid arthritis,with a significant clinical effect,and is worth promoting.