血IL-1β、IL-18、Eos水平与支气管哮喘急性发作病情程度的关系及对近期转归的预测效能探讨

The relationship between serum IL-1β,IL-18,Eos levels and the severity of acute bronchial asthma attacks and their predictive efficacy for short-term outcomes

目的:探讨血白介素(IL)-1β、IL-18、嗜酸粒细胞(Eos)水平与支气管哮喘(BA)急性发作病情程度的关系及对近期转归的预测效能。方法:选取2018年4月至2021年4月锦州中心医院BA急性发作患者86例为观察组,同期43例BA稳定期患者为对照组。比较两组血IL-1β、IL-18、Eos水平,分析BA急性发作患者血IL-1β、IL-18、Eos水平与病情程度的相关性,采用Logistic回归分析BA急性发作患者近期转归的影响因素,采用受试者工作特征(ROC)曲线分析血IL-1β、IL-18、Eos水平对BA急性发作患者近期转归的预测价值。结果:观察组血IL-1β、IL-18、Eos水平高于对照组(P<0.05);BA急性发作患者血IL-1β、IL-18、Eos水平与病情程度呈正相关(P<0.05);Logistic回归分析显示,将病情程度、血氧分压(PaO_(2))、血二氧化碳分压(PaCO_(2))控制后,血IL-1β、IL-18、Eos高表达均为BA急性发作患者哮喘未有效控制的独立危险因素(P<0.05);ROC曲线显示,血IL-1β、IL-18、Eos水平联合预测BA急性发作患者近期转归的AUC值为0.890,高于单独预测(P<0.05)。结论:BA急性发作患者血IL-1β、IL-18、Eos水平与病情程度呈正相关,且可有效预测近期转归情况,对临床诊断、评估、治疗具有指导价值。

Objective:To explore the relationship between the levels of blood interleukin-1β(IL-1β),IL-18,eosinophils(Eos)and the severity of the acute attack of bronchial asthma(BA)and the predictive ability of blood IL-1β,IL-18 and Eos levels on short-term outcomes.Methods:From April 2018 to April 2021,86 patients with acute onset of BA in Jinzhou Central Hospital were selected as the observation group,and 43 patients with stable phase of BA were selected as the control group during the same period.The blood levels of IL-1β,IL-18 and Eos were compared between the two groups.The correlation between the blood IL-1β,IL-18,Eos levels and the severity of the disease in patients with acute attack of BA were analyzed.Logistic regression was used to analyze the influencing factors of the short-term outcomes of patients with acute BA.Receiver operating characteristic(ROC)curve was used to analyze the predictive value of blood IL-1β,IL-18 and Eos on the outcome of acute BA patients.Results:The blood levels of IL-1β,IL-18 and Eos in the observation group were higher than those in the control group(P<0.05).The levels of IL-1β,IL-18 and Eos in patients with acute attack of BA were positively correlated with the severity of the disease(P<0.05).Logistic regression analysis showed that after controlling the severity of disease,partial pressure of blood oxygen(PaO_(2)),and partial pressure of blood carbon dioxide(PaCO_(2)),the high expression of IL-1β,IL-18 and Eos were independent risk factors for asthma not effectively controlled in patients with acute exacerbation of BA(P<0.05).ROC results showed that the AUC value of blood IL-1β,IL-18,and Eos combined to predict the short-term outcomes of acute BA patients was 0.890,which was higher than the single prediction(P<0.05).Conclusion:The blood levels of IL-1β,IL-18,Eos in patients with acute attack of BA are positively correlated with the severity of the disease.They can effectively predict the outcome of the disease,and they have guiding value for clinical diagnosis,evaluation,and treatment.