摘要
科技进步推动了毒理学检测技术的快速发展。然而毒理学风险评估决策工具仍相对匮乏,缺乏透明的方案评估当前毒理学研究与实践,毒性检测工具评估滞后导致毒性验证困难等问题阻碍了毒理学研究范式的转变。有学者提出将循证医学理念与毒理学实践相融合,改进毒理学研究理念与风险评估决策的技术方法。在相关学者与学术组织的推动下,循证毒理学概念与内涵逐渐明了,初步形成了研究与实践的框架,尽管仍面临诸多挑战,但也为中药毒性风险评估与安全用药决策提供了全新的思路。数智化时代为中医循证毒理学发展带来了全新的机遇和广阔的空间,中药循证毒理学从理念到方法的探索是循证毒理学发展的重要体现,也将推动循证毒理学研究与实践体系的不断丰富和完善。
Advances in science and technology promote the rapid development of toxicological detection technologies. However, there is still a lack of decision-making tools for toxicological risk assessment, such as the lack of transparent schemes to evaluate current toxicological research and practice and the lag of toxicological testing tools to evaluate toxicity, resulting in difficulties in toxicity verification and hindering the transformation of toxicological research paradigm. Some scholars have proposed to integrate the concept of evidence-based medicine with the toxicological practice to improve the technical methods of toxicological research concept and risk assessment decision-making. With the promotion of relevant scholars and academic organizations, the concept and connotation of evidence-based toxicology have gradually become clear and a framework for research and practice has been initially formed. Although there are still many challenges, it also provides a new idea for the toxicity risk assessment and safe medication decision-making of traditional Chinese medicine(TCM). The era of digital intelligence has brought new opportunities and broad space for the development of TCM evidence-based toxicology. The exploration of TCM evidence-based toxicology from concept to method is an important embodiment of the development of TCM evidence-based toxicology, and will also promote the continuous enrichment and improvement of the research and practice system of TCM evidence-based toxicology.
作者
尤良震
张心怡
关之玥
崔鹤蓉
陈昭
张晓雨
武玉卓
商洪才
YOU Liang-zhen;ZHANG Xin-yi;GUAN Zhi-yue;CUI He-rong;CHEN Zhao;ZHANG Xiao-yu;WU Yu-zhuo;SHANG Hong-cai(Dongzhimen Hospital,Beijing University of Chinese Medicine,Beijing 100700,China;Key Laboratory of Internal Medicine of Chinese Medicine,Ministry of Education,Bejing University of Chinese Medicine,Bejing 100700,China)
出处
《中国中药杂志》
CAS
CSCD
北大核心
2022年第17期4823-4828,共6页
China Journal of Chinese Materia Medica
基金
国家杰出青年科学基金项目(81725024)
中国博士后科学基金项目(2020M680471)
中华中医药学会青年求实项目(2022-QNQSKJL-02)。
关键词
循证毒理学
毒性风险评估
有毒中药
中药循证毒理学
evidence-based toxicology
toxicity risk assessment
toxic Chinese medicine
evidence-based toxicology of TCM