IL-37在儿童免疫性疾病中的作用

Role of IL-37 in childhood immune diseases

白细胞介素37(interleukin-37,IL-37)是IL-1家族中的一种抗炎细胞因子,可以通过胞内形成复合物、胞外与膜受体结合两种方式抑制固有免疫和适应性免疫。研究表明,IL-37通过调节基因转录、细胞代谢、细胞增殖和细胞因子表达在幼年特发性关节炎、川崎病、炎症性肠病、支气管哮喘、手足口病、孤独症谱系疾病等儿童免疫性疾病中发挥重要的抗炎作用。该文就IL-37的生物学特性、信号通路及其在儿童免疫性疾病中的抗炎机制进行综述。

Interleukin-37(IL-37)is an anti-inflammatory cytokine in the IL-1 family that suppresses both innate and adaptive immune responses in two ways:intracellular complex formation and extracellular binding to membrane receptors.Studies have shown that IL-37 plays an important anti-inflammatory role in childhood immune diseases such as juvenile idiopathic arthritis,Kawasaki disease,inflammatory bowel disease,asthma,hand,foot and mouth disease and autism spectrum disease by regulating gene transcription,cell metabolism,cell proliferation and cytokine expression.This article reviews the biological characteristics,signaling pathway of IL-37 and its anti-inflammatory mechanism in childhood immune diseases.