宫腔粘连动物模型建立的研究进展

Research progress on the establishment of animal model of intrauterine adhesion

宫腔粘连(intrauterine adhesion,IUA)是由宫腔手术操作、感染等导致宫腔部分或全部闭塞的妇科疾病。IUA的发生机制、疾病进展过程至今尚未阐明,具有较高的复发率、预后较差,也缺乏有效的预防粘连的药物。IUA动物模型的建立对揭露IUA的发病和药物疗效机制具有重要意义。目前用于建立模型的动物有大鼠、小鼠、兔子、犬类等,方法包括化学法、电热损伤法、机械损伤法、机械损伤联合感染法。本文分析各模型的优缺点及对临床的模拟性,为探讨IUA的发病机制、治疗策略及预防粘连等提供有效的动物模型参考。

Intrauterine adhesion(IUA)is a gynecological disease caused by uterine cavity surgeries and infections that leads to partial or total occlusion of the uterine cavity.However,the underlying mechanism(s)and progression of the disease have not yet been identified.IUA has a high recurrence rate and poor prognosis,and effective drugs to prevent adhesion are lacking.Therefore,establishing an effective animal model of IUA is of great significance for revealing the pathogenesis of IUA and the mechanism(s)governing drug effects.Rats,mice,rabbits,and other animals are currently used to establish intrauterine adhesion models.The IUA induction methods include chemical,thermal,or mechanical damage and mechanical damage combined with an infective method.We analyzed the advantages and disadvantages of various models and their clinical simulations in order to provide a precise animal model for exploring the pathogenesis,treatment strategies,and prevention of IUA.