超声辅助合成对硝基苯甲酸乙酯

Ultrasonic-Assisted Synthesis of p-Nitro-ethylbenzoate

以对硝基苯甲酸和无水乙醇为原料、对甲苯磺酸为催化剂,采用超声辅助合成对硝基苯甲酸乙酯,并通过单因素实验和正交实验对合成工艺进行了优化。结果表明,在超声时间为90 min、超声功率为240 W、催化剂用量为5.4 g、料液比为1∶4(g∶mL)、超声温度为80℃的最优条件下,对硝基苯甲酸乙酯产率可以达到91.03%;该方法与传统加热回流法比较,反应时间更短、反应温度更低、产率更高,且操作简单、重现性好。

Using p-nitrobenzoic acid and absolute ethanol as raw materials,and p-toluenesulfonic acid as a catalyst,we synthesized p-nitro-ethylbenzoate by an ultrasonic-assisted method.Moreover,we optimized the synthesis process by single-factor experiments and orthogonal experiments.The results show that the yield of p-nitro-ethylbenzoate can reach 91.03%under the optimal conditions as follows:the ultrasonic time of 90 min,the ultrasonic power of 240 W,the catalyst dosage of 5.4 g,the solid-liquid ratio of 1∶4(g∶mL),and the ultrasonic temperature of 80℃.Compared with the traditional heating reflux method,this method has the advantages of short time,low temperature,high yield,simple operation,and good reproducibility.