nCD64指数、PCT、IL-6水平与新生儿感染性肺炎病情程度的关系

Relationship between nCD64 index,PCT and IL-6 Levels and the severity of neonatal infectious pneumonia

目的:探究中性粒细胞CD64(nCD64)指数、降钙素原(PCT)、白介素-6(IL-6)水平与新生儿感染性肺炎病情严重程度的关系。方法:回顾性分析113例感染性肺炎新生儿的临床资料,依据病情严重程度分为重症组(n=36)与非重症组(n=77)。比较两组新生儿nCD64指数、血清PCT及IL-6水平,分析其新生儿感染性肺炎病情严重程度的关系。结果:重症组新生儿nCD64指数、血清PCT及IL-6水平高于非重症组(P<0.05);nCD64指数、血清PCT及IL-6水平与病情严重程度呈正相关(r=0.683,0.605,0.234;P<0.05);nCD64指数与PCT、IL-6水平正相关(r=0.481,0.246;P<0.05),PCT与IL-6水平正相关(r=0.206;P<0.05);nCD64指数、PCT、IL-6、诊断新生儿感染性肺炎诊断曲线下面积值分别为0.899、0.846、0.635,三指标联合曲线下面积值为0.942。结论:nCD64指数、血清PCT及IL-6水平与患儿病情严重程度关系密切,在评估新生儿感染性肺炎病情中有重要价值。

Objective:To explore the relationship between neutrophil CD64(nCD64)index,procalcitonin(PCT)and interleukin-6(IL-6)levels and the severity of neonatal infectious pneumonia.Methods:The clinical data of 113 neonates with infectious pneumonia were analyzed retrospectively.They were divided into severe group(n=36)and non-severe group(n=77)according to the severity of the disease.The nCD64 index,PCT and IL-6 levels were compared between the two groups,and the relationship between them and the severity of neonatal infectious pneumonia was analyzed.Results:The nCD64 index,PCT and IL-6 levels in the severe group were higher than those in the non-severe group(P<0.05).nCD64 index,PCT andIL-6 levels were positively correlated with the severity of the disease(r=0.683,0.605,0.234,P<0.05).nCD64 index was positively correlated with PCT and IL-6 levels(r=0.481,0.246,P<0.05),and PCT was positively correlated with IL-6 level(r=0.206,P<0.05).The area under the curve values of nCD64 index,PCT and IL-6 alone and incombination to diagnose neonatal infectious pneumonia were 0.899,0.846,0.635,and 0.942,respectively.Conclusion:The nCD64 index,PCT,and IL-6 levels are closely related to the severity of infectious pneumonia in children,and have important value in assessing the severity of neonatal infectious pneumonia.