龙血竭巴布剂处方的优化

Optimization of the Formula of Dragon's Blood Cataplasms

目的优化龙血竭巴布剂的基质处方和工艺。方法在单因素基础上,以初黏力、持黏力和综合感官作为评分标准,聚丙烯酸钠、甘羟铝、甘油、羧甲基纤维素钠为影响因素,正交试验法进行优化。结果龙血竭巴布剂的最佳处方组成为聚丙烯酸钠5 g,甘羟铝0.6 g,甘油40 mL,羧甲基纤维素钠1.0 g,巴布剂的成型性良好、黏性适中、皮肤追随性好、基质无残留。结论优选的龙血竭巴布剂处方配比和工艺稳定可行,可用于制备。

Objective To optimize the matrix prescription and technology of Dragon's blood cataplasms.Methods On the basis of single factor,with the initial adhesion,viscosity holding force and comprehensive sensory as grading standards,and with viscomate NP-700,dihydroxy aluminum,glycerin,carboxymethylcellulose sodium as influencing factors,and optimize with orthogonal test method.Results Best prescription composition of Dragon's blood cataplasms was as follows:5 g of viscomate NP-700,0.6 g of dihydroxy aluminum,40 mL of glycerin,1.0 g of CMC-Na.The cataplasms was with good formability,moderate viscosity,good skin follow ability,and no residue on the matrix.Conclusion The optimized prescription ratio and technology of Dragon's blood cataplasms is stable and feasible,and can be used for preparation.