生活节律干预对非酒精性脂肪肝患者的影响

Effect of Life Rhythm Intervention on Patients with Non Alcoholic Fatty Liver

目的:分析生活节律干预对非酒精性脂肪肝患者的影响。方法:回顾性选取广州市第一人民医院门诊2018年6月-2020年6月诊治的89例非酒精性脂肪肝患者作为研究对象。由于患者不能佩戴智能手环及随诊等原因失访9例,失访率为10.11%,故最后纳入80例患者进行研究。根据干预方式的不同将其分为对照组(40例)和研究组(40例)。对照组给予常规护理干预,研究组在常规护理干预的基础上给予生活节律干预。比较两组干预前及干预6、12个月后的肝功能指标、睡眠节律分型情况、运动情况、固定饮食情况、肝脏衰减及硬度数值、平均日工作时间>8 h情况。结果:干预6、12个月后,研究组AST、ALT水平均显著低于干预前(P<0.05)。干预12个月后,两组AST、ALT水平均显著低于干预6个月后(P<0.05)。干预6、12个月后,研究组AST、ALT均低于对照组(P<0.05)。干预12个月后,研究组中间型占比显著高于干预前、干预6个月后(P<0.05)。干预12个月后,研究组中间型占比显著高于对照组(P<0.05)。干预12个月后,研究组固定饮食、日均锻炼时间30~60 min占比均显著高于对照组(P<0.05),日均锻炼时间<30 min占比显著低于对照组(P<0.05)。干预12个月后,研究组肝脏衰减数值、肝脏硬度数值均显著低于对照组(P<0.05)。结论:对非酒精性脂肪肝患者应用生活节律干预,不仅能有效改善患者饮食、运动情况,还能改善其肝功能,降低肝脏衰减数值、肝脏硬度数值,从而能有效促进其病情康复。

Objective:To analyze the effect of life rhythm intervention on patients with non alcoholic fatty liver.Method:A total of 89 patients with non alcoholic fatty liver diagnosed and treated in the Outpatient Department of Guangzhou First People’s Hospital from June 2018 to June 2020 were retrospectively selected as the research objects.Because the cause of patients could not wear smart bracelets and follow-up etc,9 cases were lost,and the missed follow-up rate was 10.11%.Therefore,80 patients were finally included in the study.They were divided into control group(40 cases)and study group(40 cases)according to different intervention methods.The control group was given routine nursing intervention,and the study group was given life rhythm intervention on the basis of routine nursing intervention.The liver function indexes,sleep rhythm classification,exercise,fixed diet,liver attenuation and hardness values of the two groups before and after 6 and 12 months of the intervention were compared.The daily working time was>8 hours condition were compared between the two groups.Result:After 6 and 12 months of intervention,the levels of AST and ALT in the study group were significantly lower than those before the intervention(P<0.05).After 12 months of intervention,the levels of AST and ALT in the two groups were significantly lower than those after 6 months of intervention(P<0.05).After 6 and 12 months of intervention,AST and ALT in the study group were lower than those in the control group(P<0.05).After 12 months of intervention,the proportion of intermediate type in the study group was significantly higher than that before and after 6 months of intervention(P<0.05).After 12 months of intervention,the proportion of intermediate type in the study group was significantly higher than that in the control group(P<0.05).After 12 months of intervention,the proportions of fixed diet and average daily exercise time of 30-60 minutes in the study group was significantly higher than those in the control group(P<0.05),and the proportion of average daily exercise time of<30 minutes was significantly lower than that in the control group(P<0.05).After 12 months of intervention,the liver attenuation value and liver hardness value of the study group were significantly lower than those of the control group(P<0.05).Conclusion:The application of life rhythm intervention for patients with non alcoholic fatty liver can not only effectively improve their diet and exercise,but also improve their liver function,reduce the liver attenuation value and liver hardness value,so as to effectively promote their rehabilitation in illness.