多囊卵巢综合征患者拮抗剂方案和卵泡期长方案的治疗结果比较

Comparison of Therapeutic Results between Antagonist Regimen and Long Follicular Phase Regimen in Patients with Polycystic Ovary Syndrome

目的:探讨在体外受精-胚胎移植(IVF-ET)中采用拮抗剂方案、卵泡期长方案对多囊卵巢综合征(PCOS)患者妊娠结局的影响。方法:选取2019年1月-2020年12月于徐州市妇幼保健院生殖中心就诊的70例PCOS患者随机分为试验组(n=35)与对照组(n=35)。对照组予以拮抗剂方案,试验组予以卵泡期长方案,比较两组的促排卵情况、胚胎发育情况及妊娠结局。结果:试验组的促性腺激素(Gn)使用时间较长,Gn用量、获卵数、可利用胚数较多,可利用胚胎率、优质胚胎率、新鲜移植率显著高于对照组,全胚冷冻率显著低于对照组(P<0.05)。试验组的临床妊娠率、活产率显著高于对照组,异位妊娠率、流产率、多胎率均显著低于对照组(P<0.05)。结论:与拮抗剂方案相比,在IVF-ET中采用卵泡期长方案可有效提高PCOS患者的子宫内膜容受性,有助于提高患者的临床妊娠率,改善患者的妊娠结局。

Objective:To investigate the effect of antagonist regimen and long follicular phase regimen on pregnancy outcome of patients with polycystic ovary syndrome (PCOS) in vitro fertilization embryo transfer (IVF-ET).Method:A total of 70 patients with PCOS treated in the Reproductive Center of Xuzhou Maternal and Child Health Hospital from January 2019 to December 2020 were selected as the research object.They were randomly divided into experimental group (n=35) and control group (n=35).The control group was treated with antagonist regimen,and the experimental group was treated with long follicular phase regimen.The ovulation induction,embryonic development and pregnancy outcome of the two groups were compared.Result:The use time of gonadotropin (Gn) was longer,the dosage of Gn,the number of eggs,the number of available embryos were more,the rate of available embryos,the rate of high-quality embryos and the rate of fresh transfer in the experimental group were significantly higher than those in the control group,and the whole embryo freezing rate was significantly lower than that in the control group (P<0.05).The clinical pregnancy rate and live birth rate in the experimental group were significantly higher than those in the control group,and the ectopic pregnancy rate,abortion rate and multiple pregnancy rate were significantly lower than those in the control group (P<0.05).Conclusion:Compared with the antagonist regimen,the use of long follicular phase regimen in IVF-ET can effectively improve the endometrial receptivity of PCOS patients,improve the clinical pregnancy rate,and improve the patients’ pregnancy outcome.