血浆蛋白C在未孕育龄妇女与妊娠各期的活性变化

Changes in plasma protein C activity in pregnancy and non-pregnant women of childbearing age

目的:分析妊娠各期及未孕正常育龄妇女血浆蛋白C(PC)活性变化,探讨PC活性与妊娠期生理性高凝状态的相关性。方法:选取本院收治的孕检和分娩孕妇共计4754例,按孕早期、孕中期和孕晚期分成3个实验组;同期本院健康查体未孕正常育龄妇女1747例为对照组,比较各组PC活性差异。结果:孕早期组、孕中期组、孕晚期组及对照组PC活性(%)分别为:100.7±21.4、102.0±23.0、100.9±22.5、99.8±20.8;实验各组及对照组之间两两比较,差异均无统计学意义(P>0.05)。结论:血浆PC活性在未孕正常育龄及妊娠各期妇女间基本一致,妊娠状态和妊娠进展PC活性变化不明显,提示血浆PC活性与中国人群育龄妇女妊娠期生理性高凝状态无相关性。

Objective:To analyze the changes in plasma Protein C(PC)activity in different stages of pregnancy and non-pregnant women of childbearing age,and to explore the correlation between PC activity and physiological hypercoagulable state during pregnancy.Methods:4754 women coming to our hospital for pregnancy examination and childbirth were included in the experiment group,These women were further divided into three groups according stage of their pregnancy(first,second,and third trimester).1747 healthy nonpregnant women of childbearing age were included as the control group.The level of PC activity was compared among each group.Results:PC activity(%)of the first trimester of pregnancy group,the second trimester of pregnancy group,the third trimester of pregnancy group and the control group were:100.7±21.4、102.0±23.0、100.9±22.5、99.8±20.8,respectively.There was no statistically significant difference between the two comparisons(P>0.05).Conclusion:Plasma PC activity is basically the same among non-pregnant women of childbearing age and pregnancy.Plasma PC activity does not change significantly in pregnancy,indicating that there is no correlation between plasma PC activity and the physiological hypercoagulable state of women of childbearing age in the Chinese population.