同步放化疗与序贯放化疗对非小细胞肺癌患者近期疗效、预后及毒副反应的影响

Effects of Concurrent Chemoradiotherapy and Sequential Chemoradiotherapy on Short-term Efficacy,Prognosis and Toxic and Side Effects in Patients with Non-small Cell Lung Cancer

目的分析同步放化疗(CCRT)、序贯放化疗(SCRT)对非小细胞肺癌患者近期疗效、预后及毒副反应的影响。方法将2016年2月-2018年11月收治的107例非小细胞肺癌根据放化疗方案的不同分为研究组56例(予CCRT)与对照组51例(予SCRT)。比较2组近期疗效,治疗前后细胞角蛋白19片段(CYFRA21-1)水平,预后情况(无进展生存率、总生存率、局部复发率、远处转移率)及毒副反应。结果研究组临床总有效率为91.07%高于对照组的76.47%(P<0.05);治疗后2组CYFRA21-1均下降,其中研究组下降程度最为显著(P<0.05);研究组局部复发率、远处转移率低于对照组(P<0.05,P<0.01);2组毒副反应发生率比较差异无统计学意义(P>0.05)。结论CCRT治疗非小细胞肺癌可有效提升临床近期疗效,改善患者预后,且未显著增加毒副反应。

Objective To analyze the effects of concurrent chemoradiotherapy(CCRT)and sequential chemoradiotherapy(SCRT)on the short-term efficacy,prognosis and toxic and side effects of patients with non-small cell lung cancer(NSCLC).Methods A total of 107 patients with NSCLC who were treated from February 2016 to November 2018 were divided into the research group(treated with CCRT,n=56)and the control group(treated with SCRT,n=51)according to different radiotherapy and chemotherapy regimens.The short-term efficacy,cytokeratin 19 fragment(CYFRA21-1)level,prognosis(progression-free survival rate,overall survival rate,local recurrence rate,distant metastasis rate)and toxic and side effects were compared between the two groups before and after treatment.Results The total clinical effective rate in the research group was 91.07%,which was higher than that(76.47%)in the control group(P<0.05).After treatment,CYFRA21-1 in both groups decreased,and the decrease in the research group was the most significant(P<0.05).The local recurrence and distant metastasis rate in the research group were lower than those in the control group(P<0.05,P<0.01).There was no significant difference in the incidence of toxic and side effects between the two groups(P>0.05).Conclusion CCRT in the treatment of NSCLC can effectively improve the short-term clinical efficacy,improve the prognosis of patients,and does not significantly increase the toxic and side effects.