益气清肺化痰通络方在慢性阻塞性肺疾病急性加重期患者中的应用价值

Application Value of Yiqi Qingfei Huatan Tongluo Decoction in the Treatment of Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease

目的探讨益气清肺化痰通络方在慢性阻塞性肺疾病急性加重期(AECOPD)患者中的应用价值。方法选取2018年10月-2021年10月收治的124例AECOPD,根据治疗方法不同将其分为研究组(63例)和对照组(61例)2组。研究组在西药治疗基础上给予益气清肺化痰通络方治疗,对照组给予西药治疗。比较2组临床疗效、免疫功能指标(T淋巴细胞亚群CD3+、CD4+、CD8+、CD4+/CD8+)、炎性因子[肿瘤坏死因子-α(TNF-α)、C反应蛋白(CRP)和碱性成纤维细胞生长因子(b-FGF)]、肺功能指标[第1秒用力呼气容积(FEV1)、用力肺活量(FVC)、第1秒用力呼气容积占用力肺活量百分比(FEV1/FVC%)]及不良反应。结果治疗后,研究组总有效率高于对照组;2组CD3+、CD4+、CD4+/CD8+、FEV1、FVC、FEV1/FVC%较治疗前升高,CD8+和TNF-α、CRP、b-FGF较治疗前降低;研究组CD3+、CD4+、CD4+/CD8+、FEV1、FVC、FEV1/FVC%高于对照组,CD8+和TNF-α、CRP、b-FGF低于对照组(P<0.05)。治疗期间,2组未出现严重不良反应。结论益气清肺化痰通络方治疗AECOPD患者效果显著,可改善免疫功能和肺功能,减轻炎症反应,且安全性较好。

Objective To investigate the application value of Yiqi Qingfei Huatan Tongluo Decoction in the treatment of patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods A total of 124 AECOPD patients admitted to our hospital from October 2018 to October 2021 were collected.According to different treatment methods,they were divided into the research group(n=63)and the control group(n=61).The research group was treated with Yiqi Qingfei Huatan Tongluo Decoction on the basis of western medicine,and the control group was treated with western medicine.The clinical efficacy,immune function indexes(T lymphocyte subsets CD3+,CD4+,CD8+,CD4+/CD8+),inflammatory factors indexes[tumor necrosis factor-α(TNF-α),C-reactive protein(CRP),basic fibroblast growth factor(b-FGF)],lung function indexes[forced expiratory volume in one second(FEV1),forced vital capacity(FVC),percentage of forced expiratory volume in one second to forced vital capacity(FEV1/FVC%)],and adverse reactions were compared between the two groups.Results After treatment,the total effective rate was higher in the research group than in the control group.After treatment,CD3+,CD4+,CD4+/CD8+,FEV1,FVC,FEV1/FVC%in the two groups increased,while CD8+,TNF-α,CRP,and b-FGF levels decreased,and the increase or decrease degree of the above indexes in the research group was greater than that in the control group(P<0.05).There were no serious adverse reactions in the two groups.Conclusion Yiqi Qingfei Huatan Tongluo Decoction has a significant therapeutic effect on patients with AECOPD,which can effectively improve the immune function and lung function of patients,reduce inflammatory response,and is safe.