IgG抗-E抗体引起的新生儿溶血病1例

A case of hemolytic disease of the newborn caused by IgG anti-E

分析1例怀疑由免疫球蛋白G(IgG)抗-E抗体引起的新生儿溶血病。患儿ABO血型为O型,Rh血型分型为CcDEe,其母亲ABO血型为A型,Rh血型分型为CCDee,排除ABO、RhD溶血。对患儿外周血进行新生儿溶血三项实验,发现存在与患儿不相容的抗体,对患儿血浆、患儿红细胞放散液及其母亲血浆不规则抗体筛查及抗体特异性鉴定,结果均为IgG-E。该患儿溶血病由母体的IgG-E抗体引起,且因产前未进行不规则抗体筛查而未被发现。提倡孕妇产前进行不规则抗体筛查,有助于预防或早期诊断新生儿溶血,早期干预,减少围产儿并发症的发生。

A case of hemolytic disease of the newborn(HDFN)caused by immunoglobulin(Ig)G anti-E was analyzed in this study.The ABO and Rh blood group of the newborn was O and CcDEe,respectively.The ABO and Rh blood group of her mother was A and CCDee,respectively.Thus,the reason of ABO and RhD hemolysis were impossible.The incompatible antibodies were found in the newborn serum by three serological tests.The antibody screening and identification test using the plasma and the red blood cell eluate from the newborn and the plasma from her mother showed that the HDFN was caused by the IgG anti-E antibodies.The case was caused by failing to prenatal screening for irregular antibodies.Therefore,the prenatal screening for irregular antibodies seems necessary for pregnant women to prevent,diagnose or manage the HDFN at an early time,reducing the occurrence of perinatal complications.