纳米生物传感器在新型冠状病毒检测中的应用

The application of nano-biosensors in the detection of 2019-nCoV

当前,导致新型冠状病毒肺炎(COVID-19)的2019新型冠状病毒感染已严重威胁到全球公共卫生。临床迫切需要及时诊断COVID-19以指导流行病学措施、感染控制、抗病毒治疗和疫苗研发。纳米生物传感器由于其器件体积小、免标记、特异性好、检测时间短等优点,已实现对多种生物标志物的高性能检测并有望在未来成为2019新型冠状病毒的床旁检测工具。因此,该文概述了纳米生物传感器的工作原理及分类,重点总结了近一年来所报道的纳米生物传感器在检测2019新型冠状病毒方面的研究进展。最后,该文简要展望了纳米生物传感器所面临的挑战和未来的发展前景。

The pandemic of 2019 novel coronavirus(2019-nCoV)infection since 2020 caused Coronavirus Disease 2019(COVID-19)leads the serious threaten to global public health.It is urgent to diagnose COVID-19,guide epidemiological measures,control the infection rates,research/develop the antiviral treatment and promote the vaccine research.The application of nano-material based biosensors(the nano-biosensors)has achieved the high-performance detection of a variety of biomarkers due to their small device size,label free detection,high sensitivity,good specificity,short detection time,and has been considered as great potential to become a point-of-care testing tool for detecting 2019-nCoV.Therefore,by summarizing the working principle and classification of nano-biosensors,and focusing on the research progress of nano-biosensors in the detection of 2019-nCoV reported in the recent years,our review provides the challenges and future development prospects of the nano-biosensor in clinical laboratory.