摘要
To the Editor:As of January 27,2022,there were 363,062,293 cases and 5,645,884deaths from the COVID-19 pandemic1.The prevalent mutated strains have aggravated the global pandemic2.SARS-Co V-2 is highly mutable,and the mutations on the spike(S)protein resulted in a high transmission of COVID-19 and vaccine breakthrough infection3.For example,there is a notable decrease in neutralizing ability of BNT162b2 vaccination-elicited antibodies against the Delta and other variants4,5,and attenuation of peak viral burden and vaccine effectiveness are reduced with Delta variant6.
基金
the support of the National Key Research and Development Program of China(2021YFE0103100,China)
National Natural Science Foundation of China of China(81925035 and 81521005)
Shanghai Sci-Tech Innovation Initiative(19431903100,18430740800,China)
the Sanofi-SIBS Yong Faculty Award(China)
the Youth Innovation Promotion Association(China)。
