双嘧达莫联合人免疫球蛋白及阿司匹林治疗川崎病患儿的效果观察

Effect of dipyridamole combined with human immunoglobulin and aspirin in the treatment of children with Kawasaki disease

目的探究双嘧达莫联合人免疫球蛋白及阿司匹林治疗川崎病(Kawasaki disease,KD)患儿的临床疗效。方法选取2018年1月至2022年1月九江市妇幼保健院收治的72例KD患儿作为研究对象,采用随机数字表法将其分为对照组(36例)和观察组(36例)。对照组患儿予阿司匹林+人免疫球蛋白治疗,观察组患儿在对照组基础上加用双嘧达莫。于治疗8周后评价疗效,比较两组患儿治疗前后的临床症状改善情况及抗血小板聚集相关因子、炎症因子的变化,并记录不良反应。结果观察组患儿的治疗总有效率为97.22%,显著高于对照组的77.78%(P<0.05),手足肿胀、发热、黏膜充血、淋巴结肿大及皮疹消退时间均显著短于对照组(P<0.05);治疗后,观察组患儿的白细胞计数、红细胞沉降率、血小板计数、白细胞介素-6、C反应蛋白、降钙素原均显著低于对照组(P<0.05);两组患儿的不良反应比较差异无统计学意义(P>0.05)。结论双嘧达莫联合人免疫球蛋白及阿司匹林治疗KD效果确切,可有效改善患儿的临床症状,抑制血小板聚集,减轻炎性反应,且不良反应少。

Objective To investigate the clinical efficacy of dipyridamole combined with human immunoglobulin and aspirin in the treatment of children with Kawasaki disease(KD).Methods A total of 72 children with KD who were admitted to the Maternal and Child Health Hospital of Jiujiang City from January 2018 to January 2022 were selected as the research objects,and divided into control group(36 cases)and observation group(36 cases)by random number table method example.Control group was treated with aspirin+human immunoglobulin,and observation group was given dipyridamole in addition to control group.The efficacy was evaluated after 8 weeks of treatment,and the improvement of clinical symptoms,changes of anti-platelet agglutination-related factors and inflammatory factors were compared between the two groups before and after treatment,and adverse reactions were recorded.Results The total effective rate in observation group was 97.22%,which was higher than 77.78%in control group(P<0.05).The time of regression of swelling of hands and feet,fever,mucosal hyperemia,lymph node enlargement and rash was significantly shorter than that of control group(P<0.05).After treatment,the white blood cell count,erythrocyte sedimentation rate,platelet count,interleukin-6,C-reactive protein and procalcitonin in observation group were significantly lower than those in control group(P<0.05).There was no statistical difference in adverse reactions between the two groups(P>0.05).Conclusion Dipyridamole combined with human immunoglobulin and aspirin is effective in the treatment of KD,which can effectively improve the clinical symptoms of children,inhibit platelet aggregation,reduce inflammation,and has few adverse reactions.