摘要
目的:制备透明质酸和聚多巴胺修饰的银纳米粒(PDA-AgNPs@HA),并进行表征评价。方法:利用氧化还原法制备聚多巴胺修饰的银纳米粒(PDA-AgNPs),再进一步修饰透明质酸(HA),构建透明质酸和聚多巴胺修饰的银纳米粒(PDA-AgNPs@HA),并对其形态、粒径、电位、稳定性、紫外光谱分析、光热性能进行表征评价。结果:制备的PDA-AgNPs@HA电镜下为完整的球形,分散性良好;粒径为65.2 nm,电位为-48.73 mV;紫外扫描显示在402 nm和300 nm处有特征吸收峰;体外稳定性和光热性能良好。结论:PDA-AgNPs@HA制备工艺简单,质量可控,具有良好的体外稳定性和光热性能,为抗肿瘤纳米载体的构建提供参考。
Objective To prepare and characterize hyaluronic acid and polydopamine modified silver nanoparticles(PDA-AgNPs@HA).Methods Polydopamine modified silver nanoparticles(PDA-AgNPs)were prepared by oxidation-reduction method,and then were modified with hyaluronic acid further to construct hyaluronic acid and polydopamine modified silver nanoparticles(PDA-AgNPs@HA).The developed PDA-AgNPs@HA was characterized by morphology,particle size,zeta potential,stability,UV-vis spectroscopy and photothermal property.Results PDA-AgNPs@HA was spherical with good dispersion under transmission electron microscopy.The particle size was 65.2 nm with zeta potential of-48.73 mV.It showed characteristic absorption peaks at 402 nm and 300 nm by ultraviolet scanning analysis and exhibited good stability and good photothermal property in vitro.Conclusion PDA-AgNPs@HA was fabricated facilely with controllable quality,and exhibited good stability and photothermal property in vitro,which provided reference for the design of anti-tumor nanocarrier.
作者
苏艳颖
朱梦星
崔嘉芳
金典
张晨婧
江璐
杨宜华
Su Yanying;Zhu Mengxing;Cui Jiafang;Jin Dian;Zhang Chenjing;Jiang Lu;Yang Yihua(School of Pharmacy,Xuzhou Medical University,Xuzhou 221004,China)
出处
《广东化工》
CAS
2022年第17期52-54,共3页
Guangdong Chemical Industry
基金
江苏省大学生创新创业训练计划基金资助项目(202010313020Z)。
关键词
银纳米粒
聚多巴胺
透明质酸
光热治疗
制备
silver nanoparticles
polydopamine
hyaluronic acid
photothermal therapy
preparation