碘[^(131)I]原料液瓶中放射性废气收集装置的研制和应用

Design and Application of Device for Collecting Radioactive Waste Gas from ^(131)I Solution Vials

碘[^(131)I]放射性药品生产过程中放射性原料液瓶开启时,瓶内积存的放射性废气集中释放,易造成放射性废气污染,以至排放超标。为实现放射性废气的半自动收集与暂存,本研究结合实际生产条件,克服热室尺寸受限、耐辐照、可操作性及通用性等难点,研制一套碘[^(131)I]原料液瓶中放射性废气收集装置,并对收集的放射性废气进行测量和分析。结果表明,装置运行稳定可靠;通过收集并测量22批次的^(131)I废气放射活度,表明收集量与环境温度存在一定相关性;使用三个收集瓶可充分收集储存。碘[^(131)I]原料液瓶中放射性废气收集装置可有效收集碘[^(131)I]原料液瓶开启过程中集中释放的放射性废气,降低对操作人员和环境的辐射影响。以上结果对其他碘[^(131)I]放射性药品生产机构控制碘[^(131)I]排放有一定借鉴意义。

During the process of^(131)I-labeled radiopharmaceuticals production,the radioactive waste gas accumulated in the vials will be released immediately when the vial of^(131)I solution is opened,and it will cause pollution.A set of device for collecting radioactive waste gas from^(131)I solution vials was developed,based on radiation resistance,operation convenience and versatility of device and the size of hot cell.The purpose of semi-automatic collection and temporary storage of radioactive waste gas was realized and the collected radioactive waste gas was measured and analyzed.The results showed that the equipment ran stably and reliably.The study of 22 batches shows that,the amount of^(131)I waste gas collected had a certain correlation with the ambient temperature.Three collecting bottles can fully collect the waste gas generated.In summary,the device for collecting radioactive waste gas can effectively collect the radioactive waste gas released from^(131)I solution,reducing the impact on the environment and operators,and has great reference significance for other radioactive drug companies.