苯并噁唑类化合物的制备综合实验设计

Comprehensive Experimental Design for the Preparation of Benzoxazole Compounds

跟踪科技前沿和热点,将创新性的科研成果实施于本科实验教学将会成为高校实验教学改革的趋势。本文以2,6-二异丙基苯胺和3,5-二叔丁基-1,2-苯二酚等为原料,通过氧化,取代,还原,缩合等多步有机合成单元反应,设计合成了一种大位阻苯并噁唑类化合物。该制备实验合成路线短,工艺稳定,可操作性强。同时,该制备实验原料转化率高,体现了化学反应的原子经济性。工业“三废”少,符合绿色环保理念。该综合实验能拓展学生对当今科技前沿的视野,激发他们对科学研究的兴趣,培养他们独立思考问题、解决问题的能力,适用于药物化学和制药工程等本科专业综合实验教学。

Tracking the frontier and research highlight of science and technology and implementing innovative scientific research achievements will become the trend of experimental teaching reform in universities.Herein,a benzoxazole catalyst with large steric hindrance group were designed and synthesized from 2,6-diisopropylaniline and 3,5-di-tert-butylbenzene-1,2-diol after multistep organic reactions such as oxidation,substitution,reduction and condensation.The preparation experiment has the advantages of short synthetic route,stable process and strong operability.At the same time,the experimental material has high conversion and good atomic economy.Less industrial“three wastes”,in line with the concept of green environmental protection.The comprehensive experiment can expand students’vision of science and technology in the world today,stimulate their interest in scientific research,and cultivate their ability to think and solve problems independently.It is suitable for comprehensive experimental teaching of undergraduate majors such as pharmaceutical chemistry and pharmaceutical engineering.