磁场作用下对血浆速冻品质的实验研究

Plasma Freezing Quality under Action of Magnetic Field

本文以更高效保存新鲜冰冻血浆为研究重点,在现有速冻工艺基础上,通过添加磁场辅助冻结以进一步提高血浆品质。分析0~100 Gs磁场强度下速冻实验中血浆冰晶结构尺寸变化,由于磁场辅助速冻加速传质传热速度,冰晶生长的速度快于水分迁移的速度,导致冰晶在形态及分布上发生变化,在血浆中形成了细小、圆整、均匀的冰晶,减少冰晶对血浆完整结构的损伤,从而达到提高血浆品质的目的。对比0~100 Gs磁场强度下速冻实验中血浆凝血因子Ⅷ活性浓度与新鲜冰冻血浆凝血因子Ⅷ活性浓度可知:辅助磁场下各磁场强度凝血因子Ⅷ活性浓度均出现不同程度的降低,最大降低发生在20 Gs磁场强度作用下,下降了3.56%。相对于其他磁场强度,在60 Gs、80 Gs磁场作用下的活性浓度数值更高,速冻保存后的血浆品质更好。

In this study,the efficient preservation of fresh frozen plasma was investigated.Improving the quick freezing efficiency was achieved by adding a magnetic field to assist the freezing process.The changes in plasma ice crystal structure and size in the quick-freezing experiment under a magnetic field of 0-100 Gs were analyzed.Considering magnetic field-assisted quick-freezing accelerates the mass and heat transfer rate,the growth rate of ice crystals is faster than the speed of water migration,resulting in changes in the shape and distribution of the ice crystals.Therefore,small,round,and uniform ice crystals were formed in the plasma,which reduced the damage to the structure of the plasma by the ice crystals and thus improved the quality.The plasma coagulation factorⅧcontent in the quick-freezing experiment under 0-100 Gs magnetic field intensity was reduced by different amounts depending on the magnetic field intensity when compared with that for fresh frozen plasma.The maximum reduction of 3.56%occurred at a magnetic field of 20 Gs.The active concentration under magnetic fields of 60 Gs and 80 Gs were higher than those at other field strengths,and the plasma quality effect after quick-freezing storage was better.