老年人群肥胖指标与高尿酸血症的关系

Relationship between obesity indicators and hyperuricemia in the elderly

目的研究老年人群肥胖指标与高尿酸血症(hyperuricemia,HUA)的关系,为肥胖人群HUA的筛查与管理提供依据。方法回顾性收集参加健康体检的老年人临床资料,包括受检者的年龄、身高、体质量、SBP、DBP、血尿酸、TG、HDL-C、LDL-C、腰围等资料,计算BMI、身体圆度指数(body roundness index,BRI)、相对脂肪质量指数(relative fat mass index,RFM)、脂质蓄积指数(lipid accumulation product,LAP)及内脏脂肪指数(visceral adiposity index,VAI),分析老年人不同肥胖指标与HUA的关系。结果共获取了10582例有效的健康体检资料,HUA组与非HUA组BMI、腰围、BRI、RFM、LAP及VAI水平差异有统计学意义(P<0.05)。矫正性别、年龄、吸烟、饮酒后的多因素Logistic回归分析结果显示,腰围(OR=1.029,95%CI:1.018~1.040)、BMI(OR=1.227,95%CI:1.070~1.407)、LAP(OR=1.007,95%CI:1.003~1.011)、BRI(OR=1.474,95%CI:1.288~1.688)、RFM(OR=1.070,95%CI:1.046~1.095)与HUA有关。老年不同性别人群LAP预测HUA的AUC均最大,高于BMI、腰围、BRI、VAI、RFM。结论不同肥胖指标在老年人群中均是HUA的危险因素,在不同性别老年人群中,LAP预测HUA的价值均最大,为HUA的管理提供了依据。

Objective To explore the relationship between the indicators of obesity and hyperuricemia(HUA)in the elderly people aged≥60 years old,and to provide evidence for the screening and management of HUA.Methods The clinical data including age,height,weight,systolic blood pressure,diastolic blood pressure,blood uric acid,triglycerides,high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C)and waist circumference(WC)were collected by reviewing the physical check report,and body mass index(BMI),body roundness index(BRI),relative fat mass index(RFM),lipid accumulation product(LAP)and visceral adiposity index(VAI)were calculated.The relationship between the obesity indicators and HUA was analyzed by Logistic regression model.Results A total of 10582 cases were enrolled in this study.There were statistically significant differences in the levels of BMI,WC,BRI,RFM,LAP and VAI between HUA group and non-HUA group(P<0.05).Logistic regression analysis showed that WC(OR=1.029,95%CI:1.018-1.040),BMI(OR=1.227,95%CI:1.070-1.407),LAP(OR=1.007,95%CI:1.003-1.011),BRI(OR=1.474,95%CI:1.288-1.688)and RFM(OR=1.070,95%CI:1.046-1.095)were associated with HUA.The area under the receiver operating characteristic curve of LAP in predicting HUA was greatest.Conclusions Some obesity indicators are risk factors for HUA in the elderly,and LAP has the greatest predictive value,which provides evidence for the management of HUA.