某院儿童抗感染药物药品不良反应报告分析

Adverse Drug Reaction Reports of Anti-Infective Drugs in Children in a Hospital

目的为患儿(0~15岁)临床合理使用抗感染药物提供参考。方法收集医院2014年至2020年355例患儿使用抗感染药物发生的药品不良反应(ADR)数据,采用Excel软件对患儿的性别、年龄、给药方式、怀疑引发ADR的药品类别、ADR具体表现、转归情况进行统计分析。结果患儿以男性(222例,62.53%)、≤6岁(297例,83.66%)较多;用药类型以头孢菌素类较多(216例,60.85%),给药方式集中于静脉滴注(347例,97.75%);ADR集中发生于皮肤系统及其附件(334例,94.08%);35例(9.86%)停药及对症治疗后痊愈,308例(86.76%)好转,7例(1.97%)出现新症状或加重,5例(1.41%)不详。结论患儿使用抗感染药物时应注意其体质,给药时应注意规范操作和及时调整药物剂量,加强用药监护。

Objective To provide a reference for rational use of anti-infective drugs in children(0-15 years old).Methods Data of adverse drug reactions(ADRs)of 355 children treated with anti-infective drugs in the hospital from 2014 to 2020 were collected,and Excel software was used to statistically analyze the children’s gender and age,route of administration,categories of drug suspected to cause ADR,specific manifestations and outcomes of ADR.Results Most of the children were male(222 cases,62.53%)and≤6 years old(297 cases,83.66%).Cephalosporins were the most commonly used drugs(216 cases,60.85%),and the main route of administration was intravenous drip(347 cases,97.75%).ADR mainly occurred in the skin system and its accessories(334 cases,94.08%).A total of 35 cases(9.86%)recovered after drug withdrawal and symptomatic treatment,308 cases(86.76%)relieved,7 cases(1.97%)had new symptoms or aggravation,and 5 cases(1.41%)were unknown.Conclusion When children are treated with anti-infective drugs,we should pay attention to their physique,standardized operation and timely adjustment of drug dosage,and strengthen the medication monitoring.