可见光引发有机催化的烯烃双溴代反应

Visible Light-induced Organocatalyzed Dibromination of Alkene

卤代烃因其高反应活性经常被作为药物合成中间体,可继续进行多种官能化修饰制备多种化合物。本研究利用绿色的可见光催化手段,使用有机染料作为光催化剂,从简单的烯烃底物出发,采用NBS作为卤源,选取合适的亲核试剂,实现烯烃的双溴代反应。利用紫外-可见分光光度计测定了有机光催化剂的光学性质,探究了几种底物的反应特性,并利用核磁测试对几种产物进行了表征。

Halogenated hydrocarbons are often used as intermediates for drug synthesis because of their high reactivity, which can be further modified to produce a variety of compounds.Using green visible light photocatalysis method, organic dye as photocatalyst, NBS as halogen source, dibromination reaction of alkene was achieved starting from simple alkene substrate with appropriate nucleophile reagent.The optical properties of organic photocatalysts were determined by UV-Vis spectrophotometer.The reaction features of several substrates were investigated, and the structures of the products were characterized by NMR analysis.