摘要
This stepped-wedge cluster randomized study(1)included all pancreatectomies performed from 17 Dutch pancreatic surgery centers(all realizing>20 pancreaticoduodenectomies per year)over 22 months.The aim was to demonstrate the value of an algorithm for the early diagnosis and management of postoperative complications.This algorithm determined when to do abdominal computed tomography(CT)scan,radiological drainage,start antibiotic treatment,and remove abdominal drains.It was calculated every day from postoperative day 3 to 14.The primary endpoint was a composite of bleeding that required invasive intervention,organ failure and 90-day mortality.
