S100蛋白在子宫内膜异位症中的作用

The Role of S100 Protein in Endometriosis

S100蛋白家族是钙离子结合蛋白,由25个成员组成,与Ca^(2+)结合后在细胞内、外发挥生物学功能,调节增殖、分化、炎症、迁移和侵袭、细胞凋亡、Ca^(2+)稳态和能量代谢等多种细胞过程,与多种癌症、炎症性疾病和免疫性疾病的发生和发展密切相关。子宫内膜异位症(endometriosis,EMs)发病机制复杂,是可致盆腔疼痛、不孕等的慢性炎症性疾病,目前尚无准确、易获得的早期无创诊断方法及明确的治疗靶点。研究表明,S100B、S100A7和S100A8可通过激活核因子κB(nuclear factor-κB,NF-κB)信号通路参与炎症反应;S10013可参与新生血管生成,并通过与其他促血管生成因子协同作用促进疾病发展;S100A4、S100A6和S100P可能通过Wnt/β-连环蛋白(β-catenin)信号通路和(或)p38丝裂原激活的蛋白激酶(mitogen-activated protein kinase,MAPK)信号通路诱导细胞迁移和侵袭。综述S100蛋白家族在EMs发病机制及诊疗中作用的研究进展,为S100蛋白在EMs中的进一步应用提供思路,为寻找潜在的早期诊断标志物和治疗靶点提供借鉴。

The S100 protein family is a family of 25 members of calcium-binding proteins that bind to Ca^(2+) and perform biological functions inside and outside the cell,regulating various cellular processes such as proliferation,differentiation,inflammation,migration and invasion,apoptosis,Ca^(2+) homeostasis and energy metabolism.They are closely associated with the development of many cancers,inflammatory diseases and immune disorders.Endometriosis(EMs)has a complex pathogenesis and is a chronic inflammatory disease that can cause pelvic pain and infertility.There are no accurate and easily accessible early non-invasive diagnostic methods and clear therapeutic targets.Studies have shown that S100B,S100A7 and S100A8 can participate in the inflammatory response by activating the nuclear factor-κB(NF-κB)signaling pathway;S10013 can participate in neovascularization and promotes disease progression by synergizing with other pro-angiogenic factors;S100A4,S100A6 and S100P may induce cell migration and invasion through Wnt/β-catenin signaling pathway and/or p38 MAPK signaling pathway.The research progress on the role of S100 protein family in the pathogenesis and diagnosis of EMs is reviewed to provide ideas for further applications of S100 proteins in EMs,and to provide references for the search of potential early diagnostic markers and therapeutic targets.