摘要
Recently Akhmanova et al.reported in Science that cell division at specific locations in the tissue constitutes a novel strategy for macrophage infiltration.1 Cell infiltration or tissue invasion is a common migratory strategy used by highly motile cells.This cellular response is observed in tissue colonization during development,drives intra/extravasation of leukocytes during the immune response and is exploited by tumors for metastasis.Migrating cells employ diverse mechanisms to invade tissues,including degradation or deformation of the extracellular matrix(ECM)and cell squeezing through small pores.2 Leukocytes are professional migrating cells able to find their way through tissues with different topologies and levels of confinement.Using their nucleus,the largest and stiffest organelle in a cell,leukocytes probe the microenvironment and choose the path of least resistance when moving through small pores.
基金
Open Access funding enabled and organized by Projekt DEAL.
