摘要
In a recent study published in Cancer Cell,Low et al.shed a light on a novel DNA methylation pattern in the promoter region of the stimulator of interferon genes(STING),which may be a key factor for the“cold”tumor micro-environment(TME)of glioblastoma(GBM),contributing to its immunosuppression.1 They have demonstrated that STING expression is epigenetically silenced by cg16983159 methylation in glioma cells as well as normal brain cells and this silencing can be rescued by DNA methyltransferase(DNMT)inhibition(Fig.1).
基金
supported by grants from the National Natural Science Foundation of China(81903083 to L.Q.,31972884 to J.H.)
National Clinical Research Center for Geriatrics(Z20201007 to J.H.)
1·3·5 Project for Disciplines of Excellence,West China Hospital(ZYGD18003 to J.H.).
