摘要
A recent research article published in Science by Ritter et al.reported that endosomal sorting complexes required for transport(ESCRT)proteins mediate repair of lesions in the cell membrane caused by the pore-forming toxin perforin at sites of cytotoxic T cell engagement.1 Subsequent entry of granzymes and initiation of apoptosis of cancer cells is thus limited,leading to reduced sensitivity against T cell‑mediated cytotoxicity.1 Along these lines,this could constitute a new critical resistance mechanism for T cellbased treatment approaches.
基金
supported by the Else Kröner-Fresenius Clinician Scientist Program Cancer Immunotherapy,the Munich Clinician Scientist Program(MCSP)
the DKTK School of Oncology.This work was supported by the Marie Sklodowska-Curie Program Training Network for Optimizing Adoptive T Cell Therapy of Cancer funded by the H2020 Program of the European Union(Grant 955575,to S.K.)
the Hector Foundation(to S.K.)
the International Doctoral Program i-Target:Immunotargeting of Cancer funded by the Elite Network of Bavaria(to S.K.)
Melanoma Research Alliance Grants 409510(to S.K.)
the Else Kröner-Fresenius-Stiftung(2021_EKFK_01,to S.K.)
the German Cancer Aid(to S.K.)
the Ernst-Jung-Stiftung(to S.K.)
the LMU Munich’s Institutional Strategy LMUexcellent within the framework of the German Excellence Initiative(to S.K.)
the Bundesministerium für Bildung und Forschung(to S.K.)
the Go-Bio Initiative(to S.K.)
the m4 award of the Bavarian Ministry for Economical Affairs(to S.K.)
the European Research Council Grant 756017,ARMOR-T(to S.K.)
the German Research Foundation(DFG)(to S.K.)
the SFB-TRR 338/12021-452881907(to S.K.)
the Fritz-Bender Foundation(to S.K.)
the Deutsche José-Carreras Leukämie-Stiftung(to S.K.).
