白细胞介素基因多态性与胃癌的相关性研究进展

Research progress on the relationship between interleukin gene polymorphisms and gastric cancer

白细胞介素(IL)是常见的炎症细胞因子,可通过旁分泌及自分泌的方式对肿瘤细胞的转移、浸润、生长及血管生成等多种生物学进程产生驱动作用。胃癌是一种早期诊断较困难的消化道恶性肿瘤,其发病与多种因素有关。近年来的遗传学研究结果证实了细胞因子编码基因中的许多单核苷酸多态性(SNP)位点与多种癌症和疾病的发生、发展相关,提示IL基因多态性可能在胃癌的发生、发展、转移中起作用,与胃癌的发病风险和易感性相关。理论上可以通过对IL基因多态性的研究,寻找胃癌相关的诊治靶点相关研究,并阐明IL基因在胃癌中的调控机制,为胃癌的临床诊治提供新的证据。文章就IL基因多态性与胃癌的相关性及相关研究进展作一综述。

Interleukins(IL) are common inflammatory cytokines that can drive a variety of cellular processes including metastasis,infiltration,growth and angiogenesis of tumor cells by paracrine and autocrine means. Gastric cancer is a type of gastrointestinal malignancy that is difficult to diagnose at an early stage,and its development is related to a variety of factors. Recent genetic studies have revealed that many single nucleotide polymorphism(SNP) loci in cytokine-encoding genes are related with the development of various cancers and diseases,suggesting that IL gene polymorphisms may play roles in the occurrence,development and metastasis of gastric cancer,and it is associated with the risk and susceptibility of gastric cancer development. Theoretically,the study of IL gene polymorphisms can be used to find gastric cancer-related diagnostic and treatment targets and elucidate the regulatory mechanisms of IL genes in gastric cancer,providing a new reference for its clinical diagnosis and treatment. This review focuses on the correlation of IL gene polymorphisms of gastric cancer and its research progress.