改性氮化碳纳米药物的制备

Construction of Carbon Nitride-based Nanodrug

采用浓硝酸回流和水热处理法对三嗪结构的石墨相氮化碳(g-C_(3)N_(4))进行改性;以化疗药物盐酸阿霉素(DOX)为负载药物,探讨pH值、时间、药物浓度对纳米药物构建的影响,并借助多种手段对纳米药物进行表征。结果表明,采用浓硝酸回流和水热处理两步法可以获得水溶性良好的氮化碳(tri-HC_(3)N_(4))纳米载体;tri-HC_(3)N_(4)在pH 7.4,10 h内可以高效负载DOX,负载容量随着DOX浓度的增大而增大,最大负载容量高达2 306 mg/g,且具有pH依赖的药物释放行为。该实验为碳质药物载体的改性提供了一种研究方法,也为纳米药物的构建及后期癌症的诊疗和实时监测提供参考。

Carbon nitride-based nanocarrier was obtained by concentrated nitric acid reflux and hydrothermal treatment of the graphite phase carbon nitride(g-C_(3)N_(4)) with triazine structure,which was applied to load the chemotherapy drug DOX.The experiment optimized the optimal loading conditions,analyzed the maximum loading capacity of tri-HC_(3)N_(4) nanocarrier,verified the successful construction of nanodrug through a variety of characterization methods,and determined the optimal release conditions of nanodrug.This experiment provides a research method for the modification of carbonaceous drug carrier,and also provides important guiding significance for the construction of nano-drug and the diagnosis and treatment of cancer,and real-time monitoring in later stage.