呼吸道合胞病毒及鼻病毒感染对儿童肝功能影响的分析

Analysis of the effects of respiratory syncytial virus and rhinovirus infection on liver function in children

目的探讨呼吸道合胞病毒(RSV)感染和人鼻病毒(HRV)感染对儿童肝功能的影响。方法回顾性分析,选取2021年7月1日至2022年1月15日该院收治的单独RSV感染儿童患者50例为RSV感染组,选取同期该院收治的单独HRV感染儿童患者50例为HRV感染组,选取同期该院收治的RSV和HRV混合感染儿童患者50例为混合感染组,选取同期该院收治的无感染儿童患者30例为对照组。收集4组患儿入院24 h内首次血液检查指标白细胞计数(WBC)、中性粒细胞绝对值(NEUT#)、淋巴细胞绝对值(LYMPH#)、单核细胞绝对值(MONO#)、红细胞计数(RBC)、血红蛋白(HGB)、血细胞比容(HCT)、血小板计数(PLT)、丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)、总蛋白(TP)、清蛋白(ALB)、总胆红素(TBIL)、直接胆红素(DBIL)、尿素氮(UREA)、肌酐(CR)、尿酸(UA)和既往病史等临床资料。结果RSV感染组、HRV感染组和混合感染组儿童患者的WBC、NEUT#、MONO#、ALT和AST均高于对照组(P<0.05),经Logistic回归分析显示,RSV与HRV感染均是肝功能异常的独立危险因素(P<0.05)。各组间LYMPH#、RBC、HGB、HCT、PLT、ALB、CR和UA差异均无统计学意义(P>0.05)。结论RSV和HRV感染是儿童肝功能异常的独立危险因素,监测感染RSV和HRV的儿童患者肝功能指标有助于提示临床对患者进行及时干预。

Objective To investigate the effects of respiratory syncytial virus(RSV)infection and human rhinovirus(HRV)infection on liver function in children.Methods Retrospective analysis were used in the study,50 children with single RSV infection treated in our hospital from July 1,2021 to January 15,2022 were enrolled as RSV infection group,50 children with single HRV infection treated in our hospital in the same period were selected as the HRV infection group,50 children with mixed RSV and HRV infection treated in our hospital in the same period were selected as the mixed infection group,and 30 children without infection treated in our hospital in the same period were selected as the control group.The first blood examination results of the four groups within 24 hours after being hospitalized were collected:white blood cell count(WBC),neutrophil absolute value(NEUT#),lymphocyte absolute value(LYMPH#),monocyte absolute value(MONO#),red blood cell count(RBC),hemoglobin(HGB),hematocrit(HCT),platelet count(PLT),alanine aminotransferase(ALT),aspartate aminotransferase(AST),total protein(TP),albumin(ALB),total bilirubin(TBIL),direct bilirubin(DBIL),urea nitrogen(UREA),creatinine(CR),uric acid(UA)and previous medical history.Results WBC,NEUT#,MONO#,ALT and AST of children in RSV infection group,HRV infection group and mixed infection group were higher than those in the control group(P<0.05).Logistic regression analysis showed that RSV and HRV infection were independent risk factors for abnormal liver function(P<0.05).There was no significant difference in LYMPH#,RBC,HGB,HCT,PLT,ALB,CR and UA among the groups(P>0.05).Conclusion RSV and HRV infections are independent risk factors for abnormal liver function in children.Monitoring the indicators of liver function in children infected with RSV and HRV is helpful to prompt clinical intervention.