摘要
Since the 20th century,humans have lived through five pandemics caused by influenza A viruses(IAVs)(H1N1/1918,H2N2/1957,H3N2/1968,and H1N1/2009)and the coronavirus(CoV)severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).IAVs and CoVs both have broad host ranges and share multiple hosts.Virus co-circulation and even co-infections facilitate genetic reassortment among IAVs and recombination among CoVs,further altering virus evolution dynamics and generating novel variants with increased cross-species transmission risk.Moreover,SARS-CoV-2 may maintain longterm circulation in humans as seasonal IAVs.Co-existence and co-infection of both viruses in humans could alter disease transmission patterns and aggravate disease burden.Herein,we demonstrate how virus-host ecology correlates with the co-existence and co-infection of IAVs and/or CoVs,further affecting virus evolution and disease dynamics and burden,calling for active virus surveillance and countermeasures for future public health challenges.
基金
supported by the National Key R&D Program of China(2021YFC2300903,2021YFE0109100,and 2021YFC2301300)
Strategic Priority Research Program of Chinese Academy of Sciences(CAS)(XDB29010102)
National Natural Science Foundation of China(NSFC)(32161123001,82161148010,and 32041010)
Beijing Natural Science Foundation(M22029 and L192007)
CAS Southeast Asia Biodiversity Research Institute(151C53KYSB20210023)
Shenzhen Science and Technology Research and Development Project(JCYJ20180504165549581)
the National Science and Technology Infrastructure of China(National Pathogen Resource Center-NPRC-32)
supported by the Special Program of China Postdoctoral Science Foundation(2020T130123ZX)
supported by National Natural Science Foundation of China(NSFC)Outstanding Young Scholars(31822055)
Youth Innovation Promotion Association of CAS(Y2021034)
the Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine(ZYYCXTD-D-202208)。
