低氧诱导因子脯氨酰羟化酶抑制剂的研究进展

Research progress of hypoxia-inducible factor prolyl hydroxylase inhibitors

目的综述低氧诱导因子脯氨酰羟化酶抑制剂的研究进展。方法查找近年低氧诱导因子脯氨酰羟化酶抑制剂的相关文献,对已上市脯氨酰羟化酶抑制剂罗沙司他、伐度司他和达普司他等,正在进行临床试验的在研药物以及新型结构的脯氨酰羟化酶抑制剂进行了归纳和总结。结果与结论脯氨酰羟化酶抑制剂用于治疗慢性肾脏病引起的贫血,与传统药物相比具有很多优点,已经成为了当前研究热点。此外,发现新型结构的脯氨酰羟化酶抑制剂也是重点研究方向之一。

Objective To review the research progress of hypoxia-inducible factor prolyl hydroxylase inhibitors.Methods The relevant literatures of hypoxia-inducible factor prolyl hydroxylase inhibitors were searched in recent years.The marketed prolyl hydroxylase inhibitors such as Roxadustat,Vadadustat and Daprodustat,etc,the drugs under development in clinical trials and prolyl hydroxylase inhibitors with new structures were summarized and summarized.Results and Conclusions Prolyl hydroxylase inhibitors are used to treat anemia caused by chronic kidney diseases.Compared with traditional drugs,they have many advantages and have become a current research hotspot.In addition,the discovery of a new structure of prolyl hydroxylase inhibitor is also one of the key research directions.