摘要
Numerous recent studies have shown that myeloid-derived suppressor cells(MDSCs),a strongly heterogeneous population of immunosuppressive cells,are dysregulated in the presence of many cancers.MDSCs present different phenotypes and play prominent roles in the tumor microenvironment.To date,gene therapies targeting MDSCs are the most innovative and flexible methods to specifically modify the tumor microenvironment.Here,we summarize current studies related to the phenotypes,functions,and mechanisms of MDSCs and explore the therapeutic landscape of chemokines that affect the balance between subpopulations of MDSCs.
出处
《iLIVER》
2022年第2期81-89,共9页
国际肝胆健康（英文）
基金
supported by grants from the National Natural Science Foundation of China(No.81773067,82073217,82073218,and 82003084)
Shanghai Municipal Science and Technology Major Project(No.2018SHZDZX05)
Shanghai Municipal Key Clinical Specialty,CAMS Innovation Fund for Medical Sciences(CIFMS)(2019-I2 M-5-058)
National Key R&D Program of China(2020YFE0202200).
