摘要
Lung cancer is one of the most prevalent and malignant cancers,among which lung adenocarcinoma(LUAD)accounts for the majority and remains a major cause of cancer-related mortality worldwide(Cui et al.,2019).Despite the growing intensity of research on the pathobiology and progression of lung cancer and the fact that many genes have been identified as potential drivers and targets for therapy(Luo et al.,2019;Zhang et al.,2019),the treatment and prognosis of lung cancer patients have hardly improved.Therefore,this study aimed to investigate the precise mechanism of lung cancer development and explore efficient diagnostic and therapeutic methods for clinical treatment.
基金
supported by the National Science and Technology Major Project of China(No.2018ZX10302205)
the Major Project of Science and Technology in Henan Province(No.161100311400)
the Natural Science Foundation of Henan Province(Nos.182300410361 and 222300420306)
the Project of Basic Research Fund of Henan Institute of Medical and Pharmacological Sciences(No.2022BP0103)
the Key Scientific and Technological Project of Henan Province(Nos.212102310124 and 222102310083)
support of Henan Key Laboratory for Pharmacology of Liver Diseases where most of the experiments were performed。
