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尼达尼布治疗放射性肺炎合并免疫检查点抑制剂相关性肺炎1例

A case report of nintedanib in the treatment of radiation pneumonitis combined with checkpoint inhibitor pneumonitis
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摘要 非小细胞肺癌患者在经过放疗联合免疫治疗后可发生放射性肺炎(radiationpneumonitis,RP)合并免疫检查点抑制剂相关性肺炎(checkpointinhibitorpneumonitis,CIP)。目前RP及CIP可出现肺纤维化表现,其发生机制与进展性纤维化性间质性肺疾病相似,且尚无有效的治疗方案。本文报道1例RP合并CIP的非小细胞肺癌患者接受尼达尼布治疗的临床资料,总结其治疗过程及预后,为RP及CIP的临床治疗提供新的思路。
作者 高源 刘青 李燕 Gao Y;Liu Q;Li Y
机构地区 成都市温江区人民医院肿瘤科 四川大学华西医院肿瘤中心放疗科 四川大学华西医院肺癌中心
出处 《肿瘤预防与治疗》 2022年第9期882-886,共5页 Journal of Cancer Control And Treatment
基金 四川大学“从0到1”创新研究项目(编号:2022scuh0018)。
关键词 非小细胞肺癌 放射性肺炎 免疫检查点抑制剂相关性肺炎 尼达尼布
分类号 R734.2 [医药卫生—肿瘤] R563.19 [医药卫生—呼吸系统]
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  • 1Tyldesley S, Boyd C, Schulze K, et al. Estimating the need forradiotherapy for lung cancer : an evidence-based, epidemiologicapproach [ J]. Int J Radiat Oncol Biol Phys,2001,49 (4) :973-985. DOI; 10. 1016/S0360-3016(00)01401-2.
  • 2Machtay M,Bae K,Movsas B, et al. Higher biologically effectivedose of radiotherapy is associated with improved outcomes forlocally advanced non-small cell lung carcinoma treated withchemoradiation : an analysis of the Radiation Therapy OncologyGroup [ J]. Int J Radiat Oncol Biol Phys,2012,82 ( 1) :425-434.DOI: 10. 1016/j. ijrobp.2010.09.004.
  • 3Kong F, Ten Haken R, Schipper M, et al. High-dose radiationimproved local tumor control and overall survival in patients withinoperable/unresectable non-small cell lung cancer : long-termresults of a radiation dose escalation study [ J ]. Int J Radiat OncolBiol Phys,2005,63(2) :324-333. DOI: 10.1016/j. ijrobp.2005.02.010.
  • 4Kong FM,Ten Haken R, Eisbruch A, et al. Non-small cell lungcancer therapy-related pulmonary toxicity: an update on radiationpneumonitis and fibrosis [ J] . Semin Oncol,2005 ,32(2 Suppl 3 ):42-54. DOI; 10.1053/j. seminoncol. 2005.03.009.
  • 5Anscher MS, Kong FM, Marks LB, et al. Changes in plasmatransforming growth factor beta during radiotherapy and the risk ofsymptomatic radiation-induced pneumonitis [ J ]. Int J Radiat OncolBiol Phys, 1997, 37 ( 2 ) : 253-258. DOI: 10. 1016/S0360-3016(96)00529-9.
  • 6Goto K,Kodama T,Sekine I,et al. Serum levels of KL-6 are usefulbiomarkers for severe radiation pneumonitis [J]. Lung Cancer,2001,34(1) :141-148. DOI; 10. 1016/S0169-5002(01 )00215-X.
  • 7Zhao L,Wang L, Ji W, et al. Elevation of plasma TGF-betalduring radiation therapy predicts radiation-induced lung toxicity inpatients with non-small cell lung cancer ; a combined analysis fromBeijing and Michigan [ J ]. Int J Radiat Oncol Biol Phys, 2009 ,74(5):1385-1390. DOI: 10.1016/j. ijrobp. 2008.10.065.
  • 8Chen YY, Williams J, Ding I, et al. Radiation pneumonitis andearly circulatory cytokine markers [ J]. Semin Radiat Oncol,2002,12(1 Suppl 1) :26-33. DOI: 10.1053/srao. 2002.31360.
  • 9Trotti A,Colevas A,Setser A,et al. CTCAE v3.0: development ofa comprehensive grading system for the adverse effects of cancertreatment [ J]. Semin Radiat Oncol,2003 ,13(3) : 176-181. DOI:10.1016/S10534296(03)00031-6.
  • 10Bradley J,Graham MV, Winter K, et al. Toxicity and outcomeresults of RTOG 9311 : a phase I-II dose-escalation study usingthree-dimensional conformal radiotherapy in patients withinoperable non-small cell lung carcinoma [ J ]. Int J Radiat OncolBiol Phys,2005,61 (2):318-328. DOI: 10. 1016/j. ijrobp. 2004.06.260.

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肿瘤预防与治疗
2022年 第9期

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